非瓣膜病房颤患者血清尿酸和超敏C反应蛋白水平的变化

The Change of Serum Uric Acid and Hypersensitive C-reactive Protein in Nonvalvular Atrial Fibrillation

目的探讨非瓣膜病房颤患者血清尿酸(UA)及超敏C反应蛋白(hs-CRP)水平的变化,并探讨其临床意义。方法入选2012年12月—2013年6月该院心内科住院诊断为非瓣膜病房颤患者108例,持续性房颤50例,阵发性房颤58例,对照组为同期门诊体检窦性心律、既往无房颤病史患者50例作为对照组。测定血清UA、hs-CRP等相关指标,比较各组间血清中UA、hs-CRP水平的变化及两者之间的相关关系。结果房颤组血清UA、hs-CRP水平均高于对照组,且持续性房颤组高于阵发性房颤组,差异有统计学意义(P<0.05)。相关分析显示两者呈正相关。结论血清UA、hs-CRP水平的升高参与了房颤的发生及维持。

Objective To explore the change and clinical significance of serum uric acid （UA） and hypersensitive C-reactive pro-tein（hs-CRP） in nonvalvular atrial fibrillation. Methods 108 cases of patients admitted in Cardiovascular Department of The Peo-ple＆#39;s Hospital of Jiyuan City and diagnosed as nonvalvular atrial fibrillation from December, 2012 to June, 2013 were enrolled, in-cluding 50 cases of persistent atrial fibrillation, and 58 cases of paroxysmal atrial fibrillation. 50 cases of patients with sinus rhythm and without the history of atrial fibrillation underwent physical examination in the outpatient during the same period were selected as the control group. The levels of serum UA, hs-CRP and other related indicators were measured. The change of serum UA, hs-CRP and the relation between the two were compared between the groups. Results The serum levels of UA and hs-CRP of the atrial fibrillation group were higher than those of the control group, even more, those of the persistent atrial fibrillation group were higher than those of the paroxysmal atrial fibrillation group, the differences were statistically significant （P〈0.05）. Relation analysis showed that the serum level of uric acid and hypersensitive C-reactive protein were positively correlated. Conclusion The increased serum UA and hs-CRP were involved in the occurrence and maintenance of atrial fibrillation.