血必净对脓毒症的凝血功能影响及疗效分析

Analysis of the Impact of Xuebijing on the Coagulation Function of Sepsis and Its Efficacy

目的探讨血必净对于提高脓毒症治愈率及改善凝血功能的积极作用。方法选取该院2012年9月—2013年9月间收治的50例脓毒症患者纳入研究。两组均采取常规综合治疗方案。研究组同时静滴血必净治疗。结果 APACHEⅡ评分(治疗前/治疗后24 h/治疗后72 h):对照组为(18.36±4.66)分/(17.37±4.46)分/(14.58±3.66)分;研究组为(18.33±4.52)分/(15.62±4.12)分/(12.31±3.35)分。治疗后24 h及72 h,两组评分均下降,研究组评分低于对照组(P均<0.05)。对照组转归率为84.0%(21例),研究组转归率为92.0%(P>0.05)。血凝指标变化:治疗前两组各指标均差异无统计学意义(P>0.05)。治疗后研究组各项指标均明显改善(P<0.05);对照组除TT外其他指标均明显改善(P<0.05)。其中研究组PLT、APTT、PT、TT及FIB指标优于对照组(P<0.05)。结论运用扶正攻邪,卫气营血理论,联合应用血必净能够有效提高脓毒症临床疗效,纠正其病理过程及异常凝血。

Objective To discuss the positive effect of Xuebijing on improving the cure rate of sepsis and coagulation function. Methods 50 cases of patients with sepsis admitted in our hospital from September, 2012 to September, 2013 were included in the study. Both groups were given the routine comprehensive treatment. In addition, the study group was given intravenous drip of Xuebijing. Results The score of APACHE Ⅱ before treatment, 24h after treatment and 72h after treatment of the control group was （18.36±4.66） points, （17.37±4.46） points, （14.58±3.66） points, respectively, and that of the study group was （18.33±4.52） points, （15.62±4.12） points, （12.31±3.35） points, separately. 24 h and 72 h after treatment, the scores of both groups decreased;the scores of the study group were significantly lower than those of the control group （all P〈0.05）. The improvement rate was 84.0% in the control group （21 cases）, 92.0% in the study group （P〉0.05）. Hemagglutination indexes＆#39; changes： before treatment, there were no statistically significant differences between two groups in hemagglutination indexes （P〉0.05）. After treatment, all the hemaggluti-nation indexes of the study group significantly improved（P〈0.05）, and hemagglutination indexes of the control group except TT sig-nificantly improved （P〈0.05）. PLT, APTT, PT, TT and FIB index of the study group were superior to those of the control group （P〈0.05） Conclusion The application of fuzhenggongxie and weiqiyingxue theory combined with Xuebijing can effectively improve the clinical efficacy for sepsis, correct its pathological and abnormal blood clotting process.