氟伐他汀、贝那普利单用及联用对稳定型心绞痛患者血浆同型半胱氨酸的影响

The Effect of Fluvastatin and Benazepril Used Alone and Used in Combination on the Plasma Homocysteine of Patients with Stable Angina Pectoris

目的探讨氟伐他汀、贝那普利单用及联用对稳定型心绞痛血浆同型半胱氨酸的影响。方法选择该院门诊及住院稳定型心绞痛患者血浆HCY>15μmol/L的120例患者,随机分为4组,常规治疗组:阿司匹林+硝酸酯类药;氟伐他汀组:氟伐他汀(40 mg,1次/d)+常规治疗;贝那普利组:贝那普利(10 mg,1次/d)+常规治疗;联合治疗组:氟伐他汀(40 mg,1次/d)+贝那普利(10 mg,1次/d)+常规治疗。治疗3个月后再次测定检测HCY。结果①血浆HCY>15μmol/L 120例稳定型心绞痛患者中经治疗后,常规治疗组治疗前后差异无统计学意义(P>0.05);氟伐他汀组、贝那普利组、联合治疗组治疗后血浆HCY水平显著降低,差异有统计学意义(P<0.01);②氟伐他汀组与贝那普利组比较,差异无统计学意义(P>0.05);③联合治疗组与氟伐他汀组、贝那普利组比较,差异有统计学意义(P<0.01)。结论氟伐他汀和贝那普利具有协同作用,两者都有降低稳定型心绞痛患者血浆中HCY水平的效能。

Objective To observe the effect of fluvastatin and benazepril used alone and used in combination on the plasma homo-cysteine of patients with stable angina pectoris. Methods 120 cases of outpatients and inpatients with stable angina pectoris and plasma HCY〉 15μmol/ L in our hospital were selected and randomly divided into 4 groups, the conventional treatment group： as-pirin＋nitrates drugs;fluvastatin group：fluvastatin （40 mg, qd ） plus conventional therapy;benazepril group：benazepril （10 mg, qd ） plus conventional therapy;combination therapy group：fluvastatin （40 mg, qd）＋benazepril （10mg, qd ） plus conventional therapy. HCY was detected again after 3 months of treatment. Results ① After the treatment, of the 120 patients with stable angina pec-toris and plasma HCY〉15μmol/L, the plasma HCY level of the conventional treatment group before and after treatment showed no statistically significant difference （P〉0.05）;the plasma HCY level of fluvastatin group, benazepril group and the combination thera-py group decreased significantly after treatment, compared with that before the treatment, the difference was statistically significant （P〈0.01）;②the difference between fluvastatin group and benazepril group was not statistically significant （P〉0.05）;④ the differ-ence between the combination therapy group, fluvastatin group and benazepril group was statistically significant （P〈0.01）. Conclu-sion Fluvastatin and benazepril have a synergistic effect, both can reduce the plasma HCY levels of patients with stable angina pectoris.