摘要
目的探讨氟伐他汀、贝那普利单用及联用对稳定型心绞痛血浆同型半胱氨酸的影响。方法选择该院门诊及住院稳定型心绞痛患者血浆HCY>15μmol/L的120例患者,随机分为4组,常规治疗组:阿司匹林+硝酸酯类药;氟伐他汀组:氟伐他汀(40 mg,1次/d)+常规治疗;贝那普利组:贝那普利(10 mg,1次/d)+常规治疗;联合治疗组:氟伐他汀(40 mg,1次/d)+贝那普利(10 mg,1次/d)+常规治疗。治疗3个月后再次测定检测HCY。结果①血浆HCY>15μmol/L 120例稳定型心绞痛患者中经治疗后,常规治疗组治疗前后差异无统计学意义(P>0.05);氟伐他汀组、贝那普利组、联合治疗组治疗后血浆HCY水平显著降低,差异有统计学意义(P<0.01);②氟伐他汀组与贝那普利组比较,差异无统计学意义(P>0.05);③联合治疗组与氟伐他汀组、贝那普利组比较,差异有统计学意义(P<0.01)。结论氟伐他汀和贝那普利具有协同作用,两者都有降低稳定型心绞痛患者血浆中HCY水平的效能。
Objective To observe the effect of fluvastatin and benazepril used alone and used in combination on the plasma homo-cysteine of patients with stable angina pectoris. Methods 120 cases of outpatients and inpatients with stable angina pectoris and plasma HCY〉 15μmol/ L in our hospital were selected and randomly divided into 4 groups, the conventional treatment group: as-pirin+nitrates drugs;fluvastatin group:fluvastatin (40 mg, qd ) plus conventional therapy;benazepril group:benazepril (10 mg, qd ) plus conventional therapy;combination therapy group:fluvastatin (40 mg, qd)+benazepril (10mg, qd ) plus conventional therapy. HCY was detected again after 3 months of treatment. Results ① After the treatment, of the 120 patients with stable angina pec-toris and plasma HCY〉15μmol/L, the plasma HCY level of the conventional treatment group before and after treatment showed no statistically significant difference (P〉0.05);the plasma HCY level of fluvastatin group, benazepril group and the combination thera-py group decreased significantly after treatment, compared with that before the treatment, the difference was statistically significant (P〈0.01);②the difference between fluvastatin group and benazepril group was not statistically significant (P〉0.05);④ the differ-ence between the combination therapy group, fluvastatin group and benazepril group was statistically significant (P〈0.01). Conclu-sion Fluvastatin and benazepril have a synergistic effect, both can reduce the plasma HCY levels of patients with stable angina pectoris.
出处
《中外医疗》
2014年第12期26-28,共3页
China & Foreign Medical Treatment
基金
江门市科技局立项课题(江科【2011】94号)
项目标题:氟伐他汀
贝那普利单用及联用对稳定型心绞痛患者血浆同型半胱氨酸的影响