探讨宫颈环形电切术（LEEP）在治疗Ⅱ、Ⅲ级宫颈上皮内瘤变（CIN）的临床价值

The Clinical Value of Loop Electrosurgical Excisional Procedure（LEEP） in the Treatment of Grade Ⅱ and Grade Ⅲ Cervical Intraepithelial Neoplasia（CIN）

目的探讨宫颈环形电切术（LEEP）在治疗Ⅱ、Ⅲ级宫颈上皮内瘤变（CIN）的临床价值。方法选择该院接诊的经相关检查确诊为Ⅱ、Ⅲ级CIN的90例患者进行研究。按照随机数表法,随机均分为两组。分别采用LEEP和宫颈冷刀锥切术（CKC）对患者进行治疗。术后,记录分析两组患者的术中出血量、手术时间及术后愈合时间,并随访调查两组患者术后并发症的发生率。结果术后,发现LEEP组的术中出血量明显少于CKC组（P〈0.01）,手术时间明显短于CKC组,差异有统计学意义（P〈0.01）,术后愈合时间明显低于CKC组,差异有统计学意义（P〈0.01）。随访调查发现LEEP组患者的并发症发生率明显低于CKC组,两组比较,差异有统计学意义（χ2=4.9390,P=0.0263）。结论 LEEP对Ⅱ、Ⅲ级CIN患者进行治疗,可显著改善患者手术情况,降低术后并发症的发生率,安全性高。

Objective To investigate the clinical value of loop electrosurgical excisional procedure（LEEP） in the treatment of grade Ⅱ and grade Ⅲ cervical intraepithelial neoplasia（CIN）. Methods 90 cases of patients admitted in our hospital and diagnosed with grade Ⅱ or grade Ⅲ CIN from August, 2008 to November, 2013 were studied. According to a random number table method, they were randomly divided into two groups and treated with LEEP and cervical cold knife conization（CKC）, respectively. After surgery, the intraoperative blood loss, operative time and postoperative healing time of the patients were recorded and analyzed, and the incidence of postoperative complications of two groups of patients was investigated in the follow-up. Results After operation, it was found that the intraoperative blood loss of the LEEP group was significantly less than that of the CKC group（P〈0.01）; the operative time was significantly shorter than that of the CKC group（P〈0.01）, postoperative healing time was significantly less than that of the CKC group（P〈0.01）. The follow-up investigation showed that the incidence of postoperative complications of the LEEP group was obviously lower than that of the CKC group, the difference was statistically significant（χ2=4.9390, P=0.0263）. Conclusion For grade Ⅱ and grade Ⅲ CIN patients, LEEP can significantly improve the patients＇ conditions and reduce the incidence of postoperative complications with high safety.