反复肺炎患儿机体免疫功能变化的研究分析

Analysis of the Serum Levels of Immunoglobulins A,G,M and T Lymphocyte Subgroup in Children with Recurrent Pneumonia

目的:通过检测反复肺炎患儿免疫球蛋白、T细胞亚群的变化,探讨免疫功能检测在反复肺炎中可能的作用。方法:分别采用散射速率比浊法及流式细胞仪,检测各组儿童血清免疫球蛋白及T细胞亚群的指标变化。结果:反复肺炎患儿IgG、IgA含量均显著低于对照组儿童(P<0.01),而两组IgM含量比较差异无统计学意义(P>0.05);反复肺炎患儿T淋巴细胞亚群CD4+的百分含量及CD4+/CD8+比值均明显低于对照组儿童(P<0.01),而CD8+的百分含量则高于对照组儿童(P<0.01)。结论:反复肺炎患儿存在体液免疫、细胞免疫功能紊乱,这可能是患儿肺炎反复发作和病程迁延不愈的原因之一。

Objective：To investigate the changes in serum Immunoglobulins and T lymphocyte subgroup in children with recurrent pneumonia,and the role of immune function testing in recurrent pneumonia.Method：The expressions of Immunoglobulin and T lymphocyte subgroup were detected by rapid immune turbidimetry and flow cytometry in recurrent pneumonia children and healthy children（Control group）.Result：The levels of IgG,IgA were all significantly lower in recurrent pneumonia children than those of control group（P〈0.01）,there were no significant differences in the levels of IgM between two groups（P〉0.05）.Meanwhile the percentage of CD4＋cell and the ratio of CD4＋/CD8＋were also all significantly lower in recurrent pneumonia children than those of control group（P〈0.01）,but the percentage of CD8＋cell was significantly higher in recurrent pneumonia children than those of control group（P〈0.01）.Conclusion：There are disfunctions of cellular immunity and humoral immunity in recurrent pneumonia children,which may contribute to the pathogenesis in children with recurrent pneumonia.