软坚清脉颗粒治疗动脉硬化性闭塞症临床疗效观察

Clinical Effect of “Ruanjian Qingmai Granule”in Treating Arteriosclerosis Obliterans

目的:观察软坚清脉颗粒治疗动脉硬化性闭塞症的临床疗效。方法:纳入120例动脉硬化性闭塞症患者,随机分为治疗组和对照组,每组60例。治疗组给予软坚清脉颗粒口服治疗,对照组给予通脉颗粒口服治疗,疗程均为28 d。观察两组患者的临床疗效及主要临床症状、体征的变化,比较两组患者的踝肱指数。结果:治疗组的总有效率为91.67%,对照组为81.67%,两组临床疗效比较差异有统计学意义(P<0.05)。治疗后,治疗组患者的皮肤发凉、肢体酸胀、烧灼感、溃疡、肢体麻木、皮温降低、肤色均显著改善(P<0.01,P<0.05);对照组患者的皮肤发凉、肢体酸胀、烧灼感、皮温降低、肤色、溃疡亦显著改善(P<0.01,P<0.05);且治疗组患者的皮肤发凉、烧灼感、肢体酸胀、肤色、溃疡表现较对照组亦明显减轻(P<0.05)。治疗前后两组患者的踝肱指数组内及组间比较,其差异均无统计学意义(P>0.05)。结论:软坚清脉颗粒治疗动脉硬化性闭塞症具有较好的临床疗效。

Objective： To study the clinical effect of ＂ Ruanjian Qingmai Granule＂ on arteriosclerosis obliterans. Methods： One hundred and twenty patients of arteriosclerosis obliterans were randomly divided into two groups： the treatment group in which 60 cases were treated with ＂Ruanjian Qingmai Granule＂ and the control group in which 60 cases were treated with ＂Tongmai Granule＂, with a course of 28 days. The clinical effect and the major clinical symptoms and signs were observed, and the ankle-brachial index was detected and compared. Results： The total effective rates of treatment group and control group were 91.67% and 81.67% respectively, with statistical difference between the two groups （ P 〈 0.05 ）. After treatment, the symptoms and signs including skin cool feeling, body soreness, burning sensation, ulcers, numbness, skin temperature decreasing and skin color of patients in treatment group were significantly improved （ P 〈 0.01, P 〈 0.05 ） ; the symptoms and signs including skin cool feeling, body soreness, burning sensation, skin temperature decreasing, skin color and ulcers of patients in control group were also obviously improved （P 〈 0..01, P 〈 0.05 ） ; and the improvement of the symptoms and signs including skin cool feeling, burning sensation, body soreness, skin color and ulcers in treatment group was better than that in control group （ P 〈 0.05 ）. There was no statistical difference on the ankle-braehial index between the two groups （P 〉 0.05 ）. Conclusion： ＂Ruanjian Qingmai Granule＂ has good effect in treating arteriosclerosis obliterans.