4Fuchs CS,Tomasek J,Yong CJ,et al.Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma(regard):an international,randomised,multicentre,placebo-controlled,phase 3 trial[J].Lancet,2014,383(9 911):31.
5Wilke H,Muro K,Cutsem E,et al.Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma(RAINBOW):a double-blind,randomised phase 3 trial[J].Lancet Oncology,2014,15:1 224.
6Eli Lilly and Company.A study of ramucirumab in participants with gastric,esophageal,and gastroesophageal cancer(NCT01246960).[EB/OL][2014-10-03].http://www.clinicaltrials.gov.
7Hanahan D,Weinberg RA.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646.
