血清Ⅳ-C检测在肝纤维化诊断中的应用

Application of serum Ⅳ-C detection to the diagnosis of hepatic fibrosis

目的了解血清Ⅳ型胶原(Ⅳ-C)的含量水平在肝纤维化患者中的变化,分析Ⅳ-C对肝纤维化程度的诊断价值。方法采用放射免疫法测定110例各种病毒性肝炎患者及100例健康献血者血清Ⅳ-C水平,比较各组病毒性肝炎之间及健康献血者血清Ⅳ-C水平差异,结合病理结果进行分析。结果血清Ⅳ-C水平在肝炎患者中明显升高,以肝硬化者为最高,慢性肝炎患者与健康对照组及急性黄疸性肝炎组比较,差异有高度统计学意义(P<0.01),其升高程度与肝纤维化及肝病严重程度呈正相关。结论动态测定血清Ⅳ-C水平,可作为反映慢性肝病肝纤维化严重程度和预后的指标。

Objective To investigate the change of serum IV-C content in patients with hepatic fibrosis so so to analyze the diagnostic value of IV-C for hepatic fibrosis degree.Methods Radioimmunoassay was adopted to measure the level of serum IV-C in 110 patients with virus hepatitis and 100 healthy people, and the differences of serum IV-C in several chronic hepatitis and in healthy blood donors were compared and analyzed in combination with pathological results.Results The level of serum IV-C in patients with chronic hepatitis obviously heightened,with the highest of liver cirrhosis.The differences between chronic hepatitis sufferers and the healthy control group and acute icterohepatitis sufferers were of high statistical significance（P 〈 0.01 ）.The increased degree of serum IV-C was positively related to the degree of hepatic fibrosis and severity of liver disease.Conclusion Dynamic measurement of serum IV-C level can reflect the order of severity of hepatic fibrosis in chronic liver disease and its prognostic indicators.