2007-2012年高压氧病区感染病原菌种类及耐药性分析

Pathogens in department of hyperbaric oxygen chamber and their drug resistances in 2007-2012

目的分析我院2007-2012年高压氧病区病人感染病原菌种类及耐药变迁。方法对高压氧病区送检病人标本进行分离培养,用法国梅里埃全自动微生物分析仪进行菌种鉴定和药物敏感性试验。结果 2007-2012年我院高压氧病区病人感染病原菌以革兰阴性菌为主,占78.58%,革兰阳性菌和真菌分别占17.91%和3.51%。革兰阴性菌中以铜绿假单胞菌为主要致病菌,占阴性菌的43.00%,但分离率呈逐年下降趋势,其对多黏菌素B和头孢哌酮/舒巴坦敏感性较好,对常用抗菌药物耐药情况比较稳定。革兰阳性菌以金黄色葡萄球菌为主,占62.79%,其对利奈唑胺、万古霉素和替考拉宁敏感性最好,未出现相应耐药株。结论高压氧病区病人以呼吸系统感染为主,革兰阴性菌为主要致病菌。2007-2012年主要病原菌分离率变化趋势稳定,耐药率无明显上升趋势。

Objective To analyze the pathogens in department of hyperbaric oxygen chamber therapy and their drug resistance in 2007-2012.Methods The pathogens isolated from patients in department of hyperbaric oxygen chamber therapy were cultured and identified.Their drug susceptibility was tested using an automatic microbiology analyzer.Results The patients were mainly infected with Gram-negative bacteria,followed by Gram-positive bacteria and fungi in 2007-2012,accounting for 78.58%,17.91% and 3.51%,respectively.The leading pathogen was Pseudomonas aeruginosa isolated from Gram-negative bacteria,accounting for 43.00% of the total Gram-negative bacteria.Its isolated rate decreased year by year and its sensitivity was higher to polymyxin B and cefperazone-sulbactam with a stable resistance to common antibiotics.Staphylococcus aureus was frequently isolated from Grampositive bacteria,accounting for 62.79% of the total Gram-positive bacteria.Its sensitivity was higher to linezolid,vancomycin and teicoplanin with no resistance.Conclusion Respiratory system infection is dominant in patients receiving hyperbaric oxygen therapy and Gram-negative bacteria are the leading pathogens with a stable isolated rate and drug resistance in 2007-2012.