柴胡甘麦汤对老年女性抑郁症患者催乳素及糖脂代谢影响的临床研究

Clinical Research on the Influence of Chaihu Ganmai Decoction on Prolactin and Glucolipid Metabolism of Senile Female Patients with Depression

目的:探讨柴胡甘麦汤对老年女性抑郁症患者催乳素水平及血糖、血脂代谢的影响。方法:将110例老年女性抑郁症患者随机分为中药组和对照组,每组各55例。中药组采用柴胡甘麦汤治疗,对照组给予氟西汀片。共治疗8周,分别于服药前及服药后第2、4、8周末对患者催乳素、血糖、血脂水平进行测定,与对照组进行比较。结果:中药组治疗后第2、4、8周末催乳素水平与治疗前比较变化无明显变化,对照组治疗后第2、4、8周末催乳素水平与治疗前及同期中药组比较,差异有统计学意义(P<0.01);中药组治疗前后血糖及血脂值无明显变化,对照组血糖及血脂水平从第2周开始有升高趋势,第4、8周末血糖、血脂值明显升高,与治疗前及同期中药组比较,差异有统计学意义(P<0.05,P<0.01);治疗后第8周末两组HAMD-17评分较治疗前降低,两组比较差异无统计学意义。结论:柴胡甘麦汤在对老年女性抑郁症患者起到治疗作用的同时,对患者催乳素水平及糖脂代谢有积极作用,能显著改善抑郁症本身引起的糖脂代谢紊乱。

Objective：To study the influence of Chaihu Ganmai Decoction on prolactin and glucolipid metabolism of senile female pa- tients with depression. Methods ：110 cases of senile female patients with depression were randomly divided into Chinese medicine group and the control group, each of 55 cases. Chinese medicine group was treated with Chaihu Ganmai Decoction, and the contol group was given Fluoxetine piece. A total of eight weeks of treatment, determined prolactin, blood sugar and blood lipid levels of patients before and at the end of 2nd,4th and 8th week after medication and compared with the control group. Results：At the end of 2nd ,4th and 8th week, prolactin levels in the Chinese medicine group compared with before treatment showed that there was no significant difference. Starting from the second week, blood sugar level was increased compared with before treatment,at the end of 4th and 8th week, blood sugar lev- els compared with before treatment showed that the difference was statistically significant（ P 〈 0.05 ） , compared with the control group, there was no statistically significant difference. Comparing the blood lipid level in each time point compared with before treatment and the same period in the control group had no statistical significance. At the end of 4th and 8th week after treatment, prolactin in the con- trol group compared with before treatment and the same period in the Chinese medicine group had statistically significant difference （P 〈 0.01 ） ,blood sugar levels compared with before treatment had statistically significant difference. Conclusion：Chaihu Ganmai De- eoetion has therapeutic effect on senile female patients with depression, and positive effect on prolactin levels and glucolipid metabo- lism ,which can significantly improve glucolipid metabolic disorder caused by depression itself.