小花棘豆生物碱对小白鼠血细胞的影响

Effects of Alkaloid in Oxytropis glabra on Blood Cells in Mice

采用全自动兽用血细胞分析仪检测小白鼠胃内灌服苦马豆素、黄花碱及这2种生物碱混合物后的血常规指标,以探讨小花棘豆生物碱对小白鼠血液学的影响。结果表明,苦马豆素组在低剂量时能提高血细胞的数量,在高剂量时能降低血细胞的数量,且差异明显。黄花碱组在低剂量时几乎不影响血细胞的数量,而在高剂量时也能够显著降低红细胞、白细胞、粒细胞、淋巴细胞的数量,但对血红蛋白含量的影响不显著。2种生物碱混合组在低剂量时随着试验时间的延长,血细胞数目逐渐增多;相反,高剂量时却又逐渐降低血细胞的数目。

The blood routine indices of mice that were administrated with swainsonine, quinolizidine alkaloids and the mixture of these two kinds of alkaloid by gastric perfusion were detected by using automatic animal blood cell analyzer. And the effects of alkaloid in Oxytropis glabra on the hematological indices of mice were discussed. The results showed that swainsonine at low dose could enhance the number of blood cells and swainsonine at high dose could enhance the number of blood cells, with significant difference. Quinolizidine alkaloids at low dose almost had no effect on the number of blood cells. Quinolizidine alkaloids at high dose could significantly decrease the number of RBC, WBC, granulocyte and lymphocyte, but its effects on the content of haemoglobin was not significant. In the mixture of these two kinds of alkaloid at low dose, the number of blood cells was gradually increased with the prolonging of test time. On the contrary, the number of blood cells was gradually decreased at high dose.