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低位局部进展期直肠癌新辅助放化疗后完全缓解的后续手术治疗效果 被引量：2

Effect of Subsequent Surgical Treatment for Complete Response Cases after Neoadjuvant Chemoradiotherapy of Low Locally Advanced Rectal Cancer
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摘要 目的探讨低位局部进展期直肠癌新辅助放化疗后完全缓解病例的进一步治疗方案及效果。方法回顾性分析江苏省中医院肿瘤外科2008年1月至2010年5月期间行新辅助放化疗后初步判断达到病理完全缓解(pCR)的14例低位局部进展期直肠癌患者的临床资料。结果 14例患者中接受手术者10例,术后真正达到pCR者5例;术后2例复发或转移,其中死亡1例,1例带瘤生存,余8例患者均无瘤生存。未行手术的4例患者中,有3例复发或转移,其中2例死亡,1例带瘤生存;余1例无瘤生存。4例未行手术病例中CEA水平正常者(<5μg/L)2例(1例复发或转移),CEA升高的2例均发生转移;10例手术病例中CEA水平正常者6例(均无瘤生存,4例真正达到pCR),升高者4例(1例真正达到pCR,2例复发或转移)。结论接受新辅助放化疗后初步判断达到pCR的病例,尤其是CEA值高于正常者,应接受规范的全直肠系膜切除(TME)手术以达到根治的目的。
作者 田君 姚学权 曹勤洪 陈彻 朱旭升 许哲 李为苏 刘福坤
机构地区 南京中医药大学附属江苏省中医院肿瘤外科 南京中医药大学附属张家港市中医医院普外科
出处 《中国普外基础与临床杂志》 CAS 2014年第6期754-756,共3页 Chinese Journal of Bases and Clinics In General Surgery
关键词 直肠癌 新辅助放化疗 病理完全缓解 癌胚抗原 全直肠系膜切除术
分类号 R735.37 [医药卫生—肿瘤]
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参考文献18

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中国普外基础与临床杂志
2014年 第6期

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