帕金森病合并睡眠障碍和认知功能减退患者脑电图改变

slow wave patients with Parkinson＇s disease activity of sleep disorders and mild cognitive impairment

目的观察帕金森病（PD）合并睡眠障碍和认知功能减退患者脑电图特点。方法选择南京医科大学第一附属医院及江苏盛泽医院自2012年12月至2013年6月间收治的49例PD患者。应用统一帕金森病评分量表（UPDRS）、医院焦虑和抑郁量表（HADS）、匹兹堡睡眠量表和蒙特利尔认知评价量表（MoCA）中文版对PD患者评估，并对其进行脑电描记与相关性分析。结果与睡眠正常、认知功能正常患者相比，合并睡眠障碍和轻度认知功能障碍的PD患者脑电图存在较高的慢波发生率（分别为61．8％，65．6％）。Logistic回归分析结果显示，睡眠情况与慢波发生率呈正相关关系（OR=4．117，P=0．042）。与未出现慢波PD患者相比，脑电图出现慢波患者匹兹堡睡眠量表评分明显增高，MoCA分值明显降低，差异有统计学意义（P〈0．05）。结论合并睡眠障碍和认知功能减退的PD患者存在更多的脑电慢波活动。

Objective To observe the electroencephalogram （EEG） activity of sleep disorders and mild cognitive impairment （MCI） patients with Parkinson＇s disease （PD）. Methods Forty-nine PD patients, admitted to our hospital from December 2012 to June 2013, were examined by Parkinson＇s Disease Rating Scale, Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Scale （PSQS） and Scale Montreal Cognitive Assessment （MoCA）; electroencephalogram and their clinic features were analyzed. Results As compared with the normal sleep and non-MCI patients with PD （61.8%）, sleep disorder and MCI patients with PD showed higher incidence of slow wave （65.6%）. Logistic regression analysis showed that sleep quality was positively correlated to the incidence of slow wave （OR=4.117, P=-0.042）. PD patients with slow wave had higher PSQS scores and lower MoCA scores as compared with PD patients without slow wave. Conclusion PD patients with sleep disorder and MCI show high incidence of slow wave.