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多发性肌炎/皮肌炎伴发的间质性肺病相关血清学标志物 被引量：1

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摘要 间质性肺病（interstitial lung disease,ILD）是影响PM/DM预后的重要因素.PM/DM-ILD早期启动免疫抑制剂治疗可明显改善预后,因此提前预测ILD或早期诊断预后不良的ILD至关重要.常规监测ILD的指标肺功能及胸部高分辨率CT（HRCT）检查有助于ILD的诊断及分型,但肺功能检查结果受多种因素影响,而HRCT使患者反复暴露于X线下不利于随访监测,且两者均不具有早期诊断价值,如抗黑色素瘤分化相关基因5 （melanoma differentiation-associated gene 5,MDA5）抗体阳性的快速进展的ILD （RP-ILD）,患者在短期内即可导致呼吸衰竭、死亡.因此寻找更简便易行、易于为患者接受的预测PM/DM-ILD的指标对于改善预后具有重要意义.
作者 蒋真 李向培
机构地区 安徽医科大学附属省立医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2014年第6期422-425,共4页 Chinese Journal of Rheumatology
基金 安徽省科技厅项目（12070403052）
关键词 间质性肺病 血清学标志物 多发性肌炎 早期诊断价值 皮肌炎 预后不良 伴发 胸部高分辨率
分类号 R593.26 [医药卫生—内科学] R563 [医药卫生—呼吸系统]
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参考文献21

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二级参考文献38

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中华风湿病学杂志
2014年 第6期

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