念珠菌耐药机制研究新进展

Advances in the study of the mechanism of Candida's drug resistance

念珠菌是临床上深部真菌感染的主要致病菌,随着抗真菌药物的广泛应用,临床念珠菌耐药性变得严重。本文综述了念珠菌对各类常用抗真菌药物如唑类、多烯类、棘白菌素类等的耐药机制研究进展,为进一步开展念珠菌耐药机制研究及指导临床合理使用抗真菌药物提供理论依据。

Candida is a major pathogen responsible for deep fungal infections. The extensive use of antifungal agents has resulted in Candida having serious resistance to these antifungal drugs. This review describes advances in the study of the mechanisms by which Candida develops resistance to commonly used antifungal agents such as azoles, polyenes, and echi- nocandins in order to provide a theoretical basis for further research on the mechanism of Candida＇s drug resistance and to guide the rational use of antifungal agents.