期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Peroxiredoxin 6与肿瘤的研究进展

原文传递
导出
摘要 目前认为氧化应激是诱发肿瘤等恶性疾病的重要起因.在有氧条件下,生物代谢反应会生成大量活性氧（reactive oxygen species,ROX）,包括过氧化氢、羟基自由基和超氧阴离子等,在机体内大量堆积可产生严重的生物效应甚至导致细胞死亡.Peroxiredoxin （Prdx）是新近发现的一类抗氧化蛋白超家族,广泛存在于原核生物和真核生物中,该蛋白家族的生化功能主要是通过硫氧还蛋白还原过氧化物,对于清除代谢产生的过氧化物具有重要作用.
作者 杨海玉 刘勇
机构地区 江西省人民医院临床医学研究所 江西省人民医院病理科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2014年第6期425-427,共3页 Chinese Journal of Pathology
基金 江西省科技厅支撑计划（2010BSA13000）
关键词 PEROXIREDOXIN 诱发肿瘤 硫氧还蛋白 氧化应激 代谢反应 生物效应 过氧化物 超氧阴离子
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献32

  • 1Zhou S, Lien YC, Shuvaeva T, et al. Functional interaction of glutathione S-transferase pi and peroxiredoxin 6 in intact cells[ J]. Int J Biochem Cell Biol,2013, 45 (2) : 401-407.
  • 2Chowdhury I, Fisher AB, Christofidou-Solomidou M, et al. Keratinocyte growth factor and glucocorticoid induction of human peroxiredin 6 gene expression occur by independent mechanisms that are synergistic [ J ]. Antioxid Redox Signal, 2014,20 ( 3 ) :391-402.
  • 3Fisher AB. Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities [ J ]. Antioxid Redox Signal, 2011, 15 ( 3 ) : 831-844.
  • 4Sorokina EM, Feinstein SI, Zhou S, et al. Intraeellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3e[J]. Am J Physiol Cell Physiol, 2011, 300(6) : C1430-C1441.
  • 5Jeong J, Kim Y, Kyung Seong J, et al. Comprehensive identification of novel post-translational modifications in cellular peroxiredoxin 6[J]. Proteomies, 2012, 12(9) : 1452-1462.
  • 6Rahaman H, Zhou S, Dodia C, et al. Increased phospholipase A2 activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein[ J]. Biochemistry, 2012, 51 (27) : 5521-5530.
  • 7Godoy JR, Oesteritz S, Hanschmann EM, et al. Segment-specific overexpression of redoxins after renal ischemia and reperfusion: protective roles of glutaredoxin 2, peroxiredoxin 3, and peroxiredoxin 6[J]. Free Radic Biol Med, 2011, 51 (2) : 552- 561.
  • 8Yang D, Song Y, Wang X, et al. Deletion of peroxiredoxin 6 potentiates lipopolysaccharide-induced acute lung injury in mice [J]. Crit Care Med, 2011, 39(4) : 756-764.
  • 9Tulsawani R, Kelly LS, Fatma N, et al. Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage[J]. BMC Neurosci, 2010, 11:125.
  • 10Sofiadis A, Becker S, Hellman U, et al. Proteomic profiling of follicular and papillary thyroid tumors [ J ]. Eur J Endocrinol, 2012, 166(4) : 657-667.

二级参考文献55

  • 1Simpson PT,Reis-Filho JS,Lakhani SR.Breast pathology:beyond morphology.Semin Diagn Pathol,2010,27(1):91-96.
  • 2Ravdin PM,Siminoff LA,Davis GJ,et al.Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer.J Clin Oncol,2001,19(4):980-991.
  • 3Coldhirsch A,Ingle JN,Gelber RD,et al.Thresholds for therapies:highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009.Ann Oncol,2009,20(8):1319-1329.
  • 4Carey LA.Through a glass darkly:advances in understanding breast cancer biology,2000-2010.Clin Breast Cancer,2010,10(3):188-195.
  • 5Jatoi I,Anderson WF,Rosenberg PS.Qualitative age-interactions in breast cancer:a tale of two diseases? Am J Clin Oncol,2008,31(5):504-506.
  • 6Carey LA,Perou CM,Livasy CA,et al.Race,breast cancer subtypes,and survival in the Carolina Breast Cancer Study.JAMA,2006,295(21):2492-2502.
  • 7Silverstein MJ.The University of Southern California/Van Nuys prognostic index for ductal carcinoma in situ of the breast.Am J Surg,2003,186(4):337-343.
  • 8Carter CL,Allen C,Henson DE.Relation of tumor size,lymph node status,and survival in 24,740 breast cancer cases.Cancer,1989,63(1):181-187.
  • 9American Joint Committee on Cancer.AJCC Cancer Staging Handbook.7th ed.Chicago:Springer,2010.
  • 10Goyal A,Mansel RE.Recent advances in sentinel lymph node biopsy for breast cancer.Curr Opin Oncol,2008,20(6):621-626.

共引文献18

中华病理学杂志
2014年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部