低剂量紫杉醇联合顺铂和5-氟尿嘧啶治疗晚期胃癌的疗效

Efficacy of low-dose paclitaxel combined with cisplatin and 5-fluorouracil in treatment of advanced gastric cancer

目的观察低剂量紫杉醇联合顺铂和5-氟尿嘧啶治疗晚期胃癌的疗效及安全性。方法 45例晚期胃癌患者治疗方案:紫杉醇30mg,持续静脉泵入16h,d1-3,d8-10;顺铂5mg,静脉滴注,d1-4,d8-11;5-氟尿嘧啶0.375g,持续静脉泵入24h,d1-5,d8-12;亚叶酸钙100mg,静脉滴注,d1,d8。21d为1个疗程,化疗2个疗程后按实体瘤疗效评价标准评价疗效及WHO分级标准评价不良反应,并随访观察生存情况。结果总有效率为52.4%(22/42)。45例中位随访时间为11个月,1年生存率为48.9%(22/45)。不良反应以骨髓抑制、脱发和胃肠道反应为主,患者均可耐受。结论低剂量紫杉醇联合顺铂和5-氟尿嘧啶治疗晚期胃癌疗效好,不良反应可耐受。

Objective To observe the efficacy and safety of low-dose paclitaxel combined with cisplatin and 5-fluorouracil in the treatment of advanced gastric cancer. Methods Therapeutic regimen of 45 patients with advanced gastric cancer included continuous intravenous pumping of paclitaxel 30 mg（dl-3,d8-12） and 5-fluorouracil 0. 375 g（dl 5, dS-10）, and intravenous infusion of cisplatin 5 mg （dl-4,d8-11） and calcium folinate 100 mg（dl, d8）. After two cycles of treatment（21 days for one cycle）, the efficacy and adverse reactions were evaluated by response evaluation criteria in solid tumors and WH（Ygraded standard, respectively. The patients were foltowe＆up for 11 months in average. Results The overall effectiveness rate was 52.4% （22/42）. One year survival rate was 48.9% （22/45）. Adverse reactions included myelosuppression, alopecia and gastrointestinal reaction, which were tolerable. Conclusion Low-dose pac[itaxel combined with cisp[atin and 5-fluorouracil is effective and tolerable in the treatment of advanced gastric cancer.