类风湿关节炎合并肺间质病变的实验室指标分析

An analysis of laboratory indexes in rheumatoid arthritis associated interstitial lung disease

目的探讨类风湿性关节炎合并肺间质病变(RA-ILD)发病的相关因素。方法 RA患者81例,合并ILD患者作为RA-ILD组(38例),未合并ILD为RA组(43例),比较两组血清类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体和葡萄糖-6-磷酸异构酶(GPI)的差异。结果 RA-ILD组血清RF为(581.49±106.62)IU/ml,抗CCP抗体阳性率为88.62%,GPI为(1.44±1.36)μg/ml,均高于RA组的(377.79±155.77)IU/ml、64.87%、(1.05±1.21)μg/ml(P<0.05)。而两组血清RF阳性率和抗CCP抗体水平均无统计学差异[(84.47%vs.71.88%)和(786.59±546.57)IU/ml vs.(782.21±605.21)IU/ml](P>0.05)。结论血清RF水平、抗CCP抗体阳性率和GPI水平高的RA患者较易合并ILD。

Objective To investigate the factors related to rheumatoid arthritis（RA） associated interstitial lung disease（ILD）. Methods A total of 81 patients with RA was assigned into two groups of RA-ILD（RA complicated with ILD,38 cases） and RA（RA without ILD,43 cases）. The differences of rheumatoid factor（RF）, anti-cyclic citrullinated peptide（CCP） antibodie and glucose-6-phosphate isomerase（GPI） were compared between two groups. Results Serum levels of RF and GPI, and the positive rate of anti-CCP antibodies were significantly higher in group RA-ILD than those in group RA [（581. 49±106. 62） IU/ml vs. （377.79±155.77） IU/ml,88.62%o vs. 64.87% and （1.44±1.36） μg/ml vs. （1.05! 1.21）μg/ml] （P（0. 05）. There were no significant differences in the positive rate of RF and the level of anti-CCP antibodies between two groups[-（84. 47% vs. 71.88%） and （786.59 ±546.57） IU/ml vs. （782.21±605.21） IU/ml]（P〉0. 05）. Conclusion RA patients with high levels of RF and GPI,and anti-CCP antibodies positive are more likely to be associated with ILD.