关注湿性年龄相关性黄斑变性抗血管内皮生长因子治疗中的无应答病例

Attention to the non-responders to anti-VEGF treatment of wet age-related macular disease

抗VEGF药物已经成为湿性AMD患者的一线标准用药，但是仍有部分患者治疗后出现无应答，其原因目前仍不确切，但可能与AMD的类型、黄斑区解剖因素异常、遗传基因型的不同、AMD病变的程度及抗药反应有关。眼科医师应当关注这部分无应答病例并给予正确的处理，最大限度地避免抗VEGF药物的滥用，并积极探索适合患者最佳个性化治疗措施。（中华眼科杂志，2014，50：406-410）

Intravitreal administration of anti-vascular endothelial growth factor （ anti-VEGF） drugs has become the standard treatment for exudative age-related macular degeneration （ AMD） .However , there are some patients who do not have a sufficient response to the treatment , and some patients fail to respond to those drugs .The mechanisms of non-response to the treatment in these cases are poorly understood .These may be associated with wAMD types , vitreomacularabnormity , genetic factors, andtachyphylaxis , etc. Ophthalmologists should pay attention to those non-responders and give them the correct treatment , avoid the anti-VEGF drugs abuse and explore the best personalized treatment for those patients .