摘要
瞬时受体阳离子通道亚家族V成员5(transient receptor potential cation channel,subfamily V,member 5,TRPV5)和TRPV6为瞬时性受体电位通道(transient receptor potential,TRP)的亚家族成员,是新发现的高选择性的Ca2+跨膜转运通道,其主要负责Ca2+由细胞外向细胞内的主动跨膜运输,在机体内参与多项生理活动的调节,本文作者从TRPV5和TRPV6的结构、电生理特性和调控相关因素及其与胃肠肿瘤关系等方面进行论述,探索TRPV5和TRPV6在胃肠肿瘤形成过程中的作用及其机制.
Transient receptor potential cation channel, subfamily V, member 5 （TRPVS） and TRPV6 are the subfamily members of the transient receptor potential （TRP）, representing new highly selective Ca^2＋ membrane transport channels, which are mainly responsible for active transport of Ca^2＋ across the cell membrane and participate in regulation of many physiological activities in the body. This paper discusses the structures and electrophysiological properties of TRPV5 and TRPV6, their related factors and their relationship with gastrointestinal tumors, highlighting the role of TRPV5 and TRPV6 in the formation of gastrointestinal tumors.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第14期1966-1971,共6页
World Chinese Journal of Digestology
基金
贵州省自然科学基金资助项目
No.黔科合J字(2009)2205号~~
