心外膜脂肪组织研究新进展

New advances in the study of epicardial adipose tissue

在生理状态下,心外膜脂肪组织显示生物化学、能量供应和心脏保护的作用。在病理状态下,心外膜脂肪通过旁分泌产生促炎细胞因子,从而局部影响心脏和冠状动脉,但其机制仍不清楚。血管生成。体重减轻和药物干预可能有助于脂肪恢复生理作用。本文主要介绍心外膜脂肪组织的最新生理和病理研究,尤其是其旁分泌和自分泌在动脉粥样硬化的发生和进展中的作用。

Under physiological conditions,epicardial adipose tissue displays biochemical,mechanical and ther- mogenic cardioprotective properties. Under pathological circumstances, epicardial fat can locally affect the heart and coronary arteries through asocrine or paracrine secretion of proinflammatory ytokines. What influences this e- quilibrium remains unclear. Improted local vascularization, weight loss, and argeted pharmaceutical interventions could help to return pieardial fat to its physiological role. This review focuses on the emerging physiological and pathophysiological spects of the epicardial fat and its numerous and innovative clinical applications. Particular em- phasis placed on the paracrine/endocrine properties of picardial fat and its role in the development and progression fatheroselerosis.