急性冠状动脉综合征患者血清ICAM-1、VCAM-1及CD40L水平及葛根素对其的影响

The serum content variety of ICAM-1,VCAM-1,CD40L in acute coronary syndrome patients and the effect of Puerarin

目的:探讨急性冠状动脉综合征(acute coronary syndrome,ACS)患者血清细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)及CD40L水平变化及葛根素对其的影响,研究黏附分子在ACS中的作用,进一步探讨中药葛根素治疗冠心病的作用机理。方法:采用酶联免疫ELISA法测定ACS患者及非ACS者葛根素治疗前后血清ICAM-1、VCAM-1及CD40L水平,对两组数据进行比较。结果:治疗前,ACS组血清ICAM-1、VCAM-1及CD40L水平显著高于稳定性冠心病组和对照组(均P<0.01);治疗后,ACS葛根素组血清ICAM-1、VCAM-1及CD40L水平较ACS对照组下降显著(P<0.01)。结论:ICAM-1、VCAM-1及CD40L等炎性因子共同作用促进ACS的发生、发展,葛根素可能通过抑制该类炎性因子的表达来抑制急性血栓形成的作用。

Objective： To discuss the serum content variety of ICAM-1, VCAM-1, CD40L in acute coronary syndrome （ACS） patients, and the effect of Puerarin; Investigate the function of the cell adhesive molecule in ACS, and then explore the mechanism of Puerarin. Method： Enzyme -linked immunosorhent assay （ELISA） was used to measure the content of soluble ICAM-1 ,VCAM-1 ,CD40L in ACS patients and non-ACS controls, as well as in ACS patients with Puerarin therapy and ACS controls. The differences of ICAM-1 ,VCAM-1 ,CD40L content were compared. Result： The levels of ICAM-1, VCAM-1, CD40L were significantly higher in ACS patients than those in controls, and was significantly lower in ACS patients with Puerarin therapy than those with conventional treatment. Conclusion：The combined action of inflammatory factors just as ICAM-1, VCAM-1, CD40L promote ACS, and Puerarin probably passes to repress the expression of inflammatory factor and has the action that repress the acute thrombosis.