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Toll样受体与特应性皮炎的研究进展 被引量：7

The research advances of Toll-like receptors and the atopic dermatitis
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摘要 Toll样受体是(TLRs)是目前研究最深入的模式识别受体(PRR),通过识别和结合特异配体,激活信号通路,诱导固有免疫反应,调节获得性免疫反应,在机体的过敏、抗病毒感染、慢性炎性反应中发挥重要作用。特应性皮炎(AD)是一种常见的皮肤病,以剧烈瘙痒、皮肤屏障结构破坏、对病原体易感性增加为特点。本文就TLRs在AD患者中的表达、基因多态性、维生素D(Vit D)通过调控TLRs影响AD的发病,以及TLRs在AD发病机制中的作用进行综述。 Toll-like receptor （TLR） is one kind of the most thoroughly studied pattern recogmtlon receptors （PRRs）. TLRs signaling pathways are triggered after recognization of specific ligands. TLRs trigger innate immune responses, prime antigen-specific adaptive immunity and play an important role in the allergy, antivirus activity and chronic inflammation. Atopic dermatitis （AD） is a common skin disease, characterized by severe itching, skin bartier damage, and increased susceptibility of pathogens. Here we describe the recent advances about expressions of TLRs and genetic polymorphisms in AD patients, regulation to TLRs by vitamin D in AD delopment and the role in pathogenesis of AD.
作者 王晓菲 刘军连 司少艳
机构地区 解放军第 解放军第
出处 《基础医学与临床》 CSCD 北大核心 2014年第6期853-856,共4页 Basic and Clinical Medicine
基金 国家自然科学基金(30872284)
关键词 TOLL样受体 特应性皮炎 维生素D 基因多态性 Toll-like receptors atopic dermatitis vitamin D genetic polymorphism
分类号 R758.2 [医药卫生—皮肤病学与性病学]
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参考文献20

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二级参考文献27

  • 1谢志强,刘玲玲,窦侠,闻卫兢,王娣,朱学骏.特应性皮炎皮损角质形成细胞NF-κB表达及外用他克莫司对其的影响[J].北京大学学报（医学版）,2004,36(5):487-490. 被引量：9
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基础医学与临床
2014年 第6期

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