cTnI和NT-proBNP对老年急性心力衰竭患者预后的判断价值

The prognosis of patients with cTnI and NT-proBNP in elderly patients with acute heart failure

目的探讨肌钙蛋白I(cTnI)和N-末端脑钠肽前体(NT-proBNP)对老年急性心力衰竭患者预后的判断价值。方法分析2012年3月—2013年8月在监护病房接受治疗的急性心力衰竭患者60例的临床资料。根据治疗结局分为存活组和死亡组,比较2组患者的一般资料,检测治疗前及治疗24 h后cTnI和NT-proBNP水平改变,并探讨两者对老年急性心力衰竭患者预后的判断价值。结果老年急性心力衰竭患者60例,其中存活组34例,死亡组26例。、治疗前存活组患者的cTnI和NT-proBNP水平均低于死亡组(P<0.01);存活组和死亡组患者治疗后cTnI和NT-proBNP水平均有所下降,但差异并无统计学意义(P均>0.05);cTnI联合NT-proBNP检测对于预后预测价值的RO(曲线下面积为0.930,敏感度为91.01%、特异度为92.35%,均明显高于cTnI(分别为0.888、80.23%、83.02%)和NT-proBNP(分别为0.732、53.2l%、90.03%)。结论 cTnI和NT-proBNP联合检测对于老年急性心力衰竭患者的预后有着重要的预测价值。

Objective To explore cardiac troponin I （cTnl） and N-terminal pro brain natriuretic peptide （NT-proB- NP） to determine the value for the prognosis in elderly patients with acute heart failure. Methods Analysis of the clinical data of 60 cases of acute heart failure patients from 2012 March to 2013 August in the ICU treatment. According to the outcome of treatment, they were divided into survival group and death group. Compared general information, befbre and 24 h after the treatment cTnI and NT-proBNP level change of the 2 groups. And to explore the prognosis of elderly patients with acute heart fai-lure judgment value. Results Elderly patients with acute heart failure in 60 cases, in which the survival group had 34 cases, 26 cases in death group. Survival gl＇oup^s cTnI and NT-proBNP levels were lower than the death group before treatment （P 〈 0.01 ）;survival group and death group patients ＇after treatment, cTnI and NT-proBNP level were decreased, but the difference was not significant （ P 〉 0.05 ） ; cTnI combined with NT-proBNP detection＇s ROC curve of prognostic value was 0.930, the sensitivity was 91. 01%, specificity was 92. 35%, obviously higher than that of cTnI （0. 888, 80.23%, 83.02% ） and NT-proBNP （0.732, 53.21%, 90.03% respectively）. Conclusion The combination of cTnI and NT-proB- NP has important predictive value for the prognosis of elderly patients with acute heart failure.