摘要
目的：考察盐酸普萘洛尔乳膏对动物皮肤的毒性作用。方法采用不同浓度（2％、5％、10％）的盐酸普萘洛尔乳膏对家兔进行皮肤刺激性试验、对豚鼠进行过敏性试验、对Wistar大鼠进行急性毒性试验及长期毒性试验。结果2％、5％盐酸普萘洛尔乳膏对完整、破损皮肤均无刺激性、急性毒性，对完整皮肤无明显毒性，不产生致敏作用，10％有轻微刺激性，可自行缓解。结论2％～5％盐酸普萘洛尔乳膏是较安全的外用制剂。
Objective To study the toxic action of propranolol hydrochloride cream on animal skin.Methods Dermal irritation test, dermato-allergic test,acute toxicity test and long-term toxicity test were conducted in rabbits,guinea pigs,Wistar rats respectively with different concentrations,including 2%,5%and 1 0%of propranolol hydrochloride cream.Results 2%and 5%propranolol hydrochloride cream had no acute toxicity or irritation to the intact or damaged skin and had no sensitization or overt toxicity to the intact skin. 1 0% propranolol hydrochloride cream had slight irritation,which could relieve spontaneously.Conclusion 2% and 5% propranolol hydrochloride creams are relatively safe external preparation.
出处
《安徽医药》
CAS
2014年第6期1020-1023,共4页
Anhui Medical and Pharmaceutical Journal
基金
山东省科技发展项目(No 2012YD18056)
关键词
盐酸普萘洛尔乳膏
皮肤刺激性
过敏性
急性毒性
长期毒性
propranolol hydrochloride cream
dermal irritation
hypersensitivity
acute toxicity
long-term toxicity
