新生儿大肠埃希菌败血症不同发病时间药物敏感特点及治疗分析

Sensitive characteristics of neonatal Escherichia coli sepsis drugs at different onset time and treatment of the disease

目的分析新生儿大肠埃希菌败血症药物敏感特点。方法选取该院2010年3月—2013年4月收治的38例新生儿大肠埃希菌败血症患儿,对其进行药敏试验观察。结果早发组ESBLs检出率显著低于晚发组(P<0.05);晚发组患儿复方新诺明、头孢呋辛、头孢曲松、头孢噻肟、哌拉西林、氨苄西林/舒巴坦、替卡西林/克拉维酸耐药率高于早发组,差异有统计学意义(P<0.05)。结论可以根据药敏试验结果选择抗生素进行治疗,以提高治疗效果。

Objective To study the sensitive characteristics of neonatal Escherichia coli sepsis drug. Methods Thirty-eight confirmed eases of neonatal septicemia caused by E. coli in the Neonatal Intensive Care Unit of Lingui People＇ s Hospital from March 2010 to April 2012 were retrospectively analyzed with regard to the antibiotic sensitivity of the pathogen. Results The ESBLs detection rate of early onset group was significantly lower than that of late onset group （ P 〈 0.05 ）. The resistence rates in late onset group to cotrimoxazole, cefuroxime, ceflriaxone, cefotaxime, piperacilfin, ampicillin/shubatan, ticarcillin / clavulanic were higher than those in early onset group with significant difference （ P 〈 0.05 ）. Conclusions It is feasible to treat the infection on drug sensitivity results which can increase rational administration of drugs.