氟比洛芬酯联合地塞米松在腹腔镜胆囊切除术后的临床观察

Clinical observation of the effects of flurbiprofen axetil combined withdexamethasone analgesia on patients undergoing laparoscopic cholecystectomy

目的探讨氟比洛芬酯联合地塞米松对腹腔镜胆囊切除患者镇痛效果及预防术后恶心、呕吐的作用。方法选择择期行腹腔镜胆囊切除术的患者240例,随机双盲分成氟比洛芬酯1 mg·kg-1联合地塞米松10 mg组(A组);氟比洛芬酯1 mg·kg-1组(B组);对照组:生理盐水5 mL(C组),所有患者均接受同种药物静脉复合麻醉。观察术后1、3、6、12、24 h的VAS评分及术后24 h内恶心、呕吐的发生率。结果术后各时间点VAS评分A组和B组显著低于C组(P<0.05);术后6、12、24 h VAS评分A组比B组低,差异有统计学意义(P<0.05);A组患者术后胃肠道反应较其他两组明显减少(P<0.05),B组和C组比较差异无统计学意义(P>0.05)。结论氟比洛芬酯联合地塞米松镇痛明显,有效延长术后镇痛时间,副作用小,是良好的镇痛方法,并能有效减少患者术后恶心、呕吐等不适症状。

Objective To investigate analgesia effect of flurbiprofen axetil combined with dexamethasone on postoperative pain and postoperative nausea and vomiting. Methods Two hundred and forty patients undergoing selective LC operation were randomly assigned into three groups： group A received flurbiprofen axetil 1 mg·kg^-1 combined with dexamethasone 10 mg,group B flurbiproien axetil 1 mg·kg^-1 and group C physiological saline ,5 mL. Visual analgesia scale（VAS） , side effects were recorded at 1 , 3,6,12,24 h after operation. Results VAS in group A and B were lower than group C at each time point （ P 〈 0.05 ） ; VAS in group A was lower than group B at 6,12,24 h time point（ P 〈 0.05 ）. The incidence of nausea and skin itching in group A were lower than those in group B and C （ P 〈 0.05 ）. There were no difference between group B and C （ P 〉 0.05 ）. Conclusions Flurbiprofen axetil combined with dexamethasone can extend the time of postoperative analgesia and reduce the adverse effect, which has synergistic analgesia effect.