紫杉醇致周围神经毒性研究进展

Research Progress on Paclitaxel-Induced Peripheral Neuropathy

紫杉醇是临床上常用的抗肿瘤药,其使用常常受到外周神经毒性的限制,文章就紫杉醇的周围神经毒性的机制及治疗进行综述,以期深入地认识周围神经毒性的发病机制,为治疗寻找新的靶点提供依据。

Taxol is a common clinical antitumor medicine. Peripheral neurotoxicity has dose-related side effect of paclitaxel therapy. In this paper, paclitaxel peripheral nerve toxicity mechanisms and treatment were reviewed in order to in-depth understand the pathogenesis of peripheral neurotoxicity, finding new treatment targets.