氟桂利嗪联合舒马普坦治疗104例丛集性头痛急性发作期的效果分析

Analysis of the effect of Flunarizine combined with Sumatriptan on acute cluster headache

目的探究氟桂利嗪联合舒马普坦治疗丛集性头痛急性期的效果。方法 104例丛集性头痛患者分为实验组与对照组,实验组使用氟桂利嗪于舒马普坦联合治疗,对照组仅用舒马普坦治疗,比较2组治疗后丛集期长度减少时间、发作次数、头痛程度及总有效率等。结果 2组治疗后较治疗前丛集期的长度、发作次数及头痛程度都明显降低,差异有统计学意义(P<0.05)。实验组丛集期长度、发作次数以及头痛程度均明显低于对照组,差异有统计学意义,(P<0.05)。实验组的总有效率98.08%,对照组为86.54%,实验组明显高于对照组(χ2=6.407,P=0.040)。结论氟桂利嗪联合舒马普坦治疗丛集性头痛急性期比单独使用舒马普坦效果更优。

Objective To evaluate the effect of Flunarizine combined with Sumatriptan on acute cluster headache. Methods Totally 104 patients with acute cluster headache were selected ,and were divided into the experimental group and the control group ,the first group were treated with Flunarizine combined with Sumatriptan ,the last group were treated only by Sumatrip-tan. After the treatment ,the severity of headache and the total efficacy rate of two groups were compared.Results The severi-ty of headache of the two groups was lower than that of before treatment （P〈0.05）.The severity of headache of the experimen-tal group was lower than that of the control group.The total efficacy rate of the experimental group was higher than that of the control group（98.08% vs 86.54% ,χ2 =6.407 , P=0.040）.Conclusion The combination of Flunarizine and Sumatriptan has better efficacy on acute cluster headache than Sumatriptan.