癫痫患儿采用静脉注射免疫球蛋白治疗的疗效及可能机制分析

Analysis of efficacy of intravenous immunoglobulin in the treatment of children with epilepsy and its possible mechanisms

目的观察采用静脉注射免疫球蛋白(INIG)治疗癫痫患儿的疗效,并对其发病的机制进行分析。方法这74例癫痫患儿随机平均分成2组,每组37例。将选取其中一组采用在卡马西平治疗同时静脉注射免疫球蛋白(INIG)进行治疗的癫痫患儿作为观察组,将选取另一组采用卡马西平治疗同时添加托吡酯进行治疗的癫痫患儿作为对照组。观察2组治疗后的临床效果。结果经过治疗后,2组的临床效果有明显的不同,观察组的总有效率(89.19%)明显高于对照组的总有效率(62.17%),差异有统计学上意义(P<0.05)。并且治疗后,观察组的癫痫患儿的淋巴细胞亚群等降低的程度明显优于对照组的癫痫患儿,差异有统计学上意义(P<0.05)。结论癫痫患儿采用静脉注射免疫蛋白(INIG)治疗的疗效更显著,值得广泛运用在临床上。

Objective To observe the efficacy of intravenous immunoglobulin （INIG） in the treatment of epilepsy in children and analyze the possible mechanisms .Methods Seventy -four children with epilepsy treated in our hospital were selected as the research objects ,and were randomly divided them into two equal groups ,37 cases in each group .The group treated with intravenous immunoglobulin （INIG） as the observation group ,another group was treated with add topiramate as the control group .The clinical efficacy was observed and the possible mechanisms of children with epilepsy after treatment in the two groups were comparatively analyzed .Results After treatment ,the clinical efficacy of two groups were significantly different , the total effective rate of observation group （89 .19% ） was significantly higher than that of control group （62 .17% ） ,it was statistically significant （P〈0 .05） .And the reduced degree of lymphocyte subpopulation in children with epilepsy of observation group was significantly better than the control group after treatment ,it was statistically significant （P〈0 .05） .Conclusion The efficacy of intravenous immunoglobulin （INIG） in the treatment of children with epilepsy is significant ,it is worthy of wide application in clinic .