摘要
目的 评估曲唑酮治疗抑郁症的效果。方法 应用曲唑酮 (男性 1 3例 ,女性 6例 ;年龄 3 6.2± 1 3 .7岁 )与阿米替林(男性 1 1例 ,女性 8例 ,年龄 3 4 .6± 1 2 .5岁 )治疗抑郁症 3 8例 ,并进行随机双盲对照。初始剂量均为 50 mg/日 ,PO,1 0日内渐增至 1 50～ 3 0 0 mg/日 ,观察 6周。采用 HAMD、HAMA及 TESS量表评定。结果 曲唑酮与阿米替林疗效相仿。HAMD总分及其因子分 ,HAMA评分疗后均比疗前显著降低 ,但 2组间比较 ,差别均无显著意义 (P>0 .0 5)。曲唑酮的主要不良反应为镇静 ,其对植物神经及心血管方面的影响明显较阿米替林为轻。
Objective To evaluate the efficacy and side-effects of trazodone.Methods A double-blind controlled trial was designed for comparing trazodone(M13,F6;age 36.2±13.7Ys)with amitriptyline(M11,F8;age 34.6±12.5Ys)to treat depression.50mg/d as the initial dose was gradually increased to 150～300mg/d within ten days for 6 weeks.Their efficacy and side-effects were evaluated by Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA) and Treatment Emergent Symptoms Scale(TESS)before and after the treatment.Results There was no significant difference in recovery ratio and reduction of scores of HAMD and HAMA betwen trazodone and amitriptyline group.The common side effects of trazodone was calm.There were much less vegetative nervous system and cardiovascular effects in trazodone than in amitriptyline group.Conclusion Trazodone is a safe and effective antidepressant drug.
出处
《健康心理学杂志》
2001年第2期143-145,共3页
Health Psychology Journal
