临床常见致病菌对美洛西林/舒巴坦等4种抗菌药物体外抗菌活性研究

Study of the Antimicrobial activity in vitro of Domestic Mezlocillin/Sulbactam and Other Three Antimicrobials

目的 对比研究美洛西林 /舒巴坦 (ML BT)与抗菌药物替卡西林 /克拉维酸 (特美汀 ,TMT)、美洛西林(ML XL )和哌拉西林 /三唑巴坦 (他唑西林 ,TZXL )对 179株临床分离菌的体外抗菌活性。方法 采用琼脂平板稀释法测定最低抑菌浓度 (MIC)。结果 ML BT对临床常见致病菌的体外抗菌活性较单用等剂量的 ML XL高 1～2倍 ,ML BT对产酶率较高的大肠埃希菌、肠杆菌属细菌、不动杆菌属细菌敏感率显著高于 ML XL (P<0 .0 1) ;对肠杆菌科属细菌、其他 G- 杆菌敏感率高于 TMT(P<0 .0 1) ;ML BT和 TZXL的抗菌谱和抗菌活性基本相似 ,敏感率基本等同 ,MIC5 0 后者较前者低 1～ 2倍 ,但差异无统计学意义。结论 ML BT的抗菌谱、体外抗菌活性与TZXL相似 ,强于 TMT、ML XL。

OBJECTIVE The antimicrobial activity in vitro of mezlocillin/sulbactam(MLBT),piperacillin/tazobactam(Tazocillin,TZXL),mezlocillin(MLXL) and ticarcillin/clavulanic acid(Timentin TMT) against 179 clinical isolates was studied.METHODS MICs were determined by agar dilution method.RESULTS The antimicrobial activity in vitro of MLBT against clinical bacteria was 1 2 times higher than that of MLXL.In vitro,MLBT has higher susceptibility than MLXL against Escherichia coli which have higher rate producing β lactamase,such as Enterobacter species,Acinetobacter species,et al.,and has higher susceptibility than TMT against Enterobacter and other G bacillus(P<0.01).MLBT and TZXL have similar antibacterial spectrum and activity susceptible rate.MIC 50 of TZXL was 1 2 times lower than that of the MLBT,but there were no siginficant differences. CONCLUSIONS The antimicrobial spectrum and antimicrobial activity in vitro of MLBT were similar to that of TZXL.