66例小儿血流感染血培养病原菌分布与耐药性分析

Pathogenic bacteria distribution of pediatric bloods stream infections and bacterial resistance:a study of 66 cases

目的 分析小儿血流感染患者病原菌分布特点及对抗菌药物的耐药情况。方法 对2013年1～6月小儿血流感染患儿血中分离到的66株病原菌进行回顾性分析。结果 血培养阳性菌株分布中革兰阳性菌占84．85％（56/66），其中凝固酶阴性葡萄球菌（CNS）65．15％（43/66）；革兰阴性菌占15．16％（10/66）。结论 小儿血流感染中首位致病菌为CNS ，且耐甲氧西林凝固酶阴性葡萄球菌（MRCNS ）耐药情况严重，应合理使用抗菌药物，减少细菌耐药性。

Objective To analyze the Pathogenic bacteria distribution of pediatric blood stream infections and bacterial resistance so as to provide basis for clinical treatment .Methods 66 cases of confirmed pediatric blood stream infections clinical data ,blood culture results and drug susceptibility testing were analyzed through retrospective analysis .Results In the positive blood culture ,gram-positive bacteria accounted for 84 .85% （56/66） ,mainly in coagulase-negative staphylococci （65 .15% ,43/66 ）;Gram-negative bacteria accounted for 15 .16% （10/66 ） . Conclusion T he data show that coagulase-negative staphylococci is the main pathogen of pediatric blood stream infections ,and MRCNS drug resistance is serious ,suggesting that antibiotics should be rationally used to reduce the generation of drug resistance of bacteria .