RBC-Y和RET-Y在肾性贫血患者铁缺乏监测中的应用

Application of RBC-Y and RET-Y in monitoring renal anemia patients with iron deficiency

目的探讨RBC-Y和RET-Y在肾性贫血患者铁缺乏监测中的应用价值。方法收集慢性肾衰竭(CRF)引起的肾性贫血组和健康对照组血液标本,分别检测RBC-Y、RET-Y、铁蛋白(SF)、可溶性转铁蛋白受体(sTfR)等指标,以sTfR>2.25mg/L作为铁缺乏的"金标准",利用ROC曲线分析RBC-Y、RET-Y和SF等参数在诊断肾性贫血患者铁缺乏的性能。结果肾性贫血组与健康对照组间RBC-Y和RET-Y两参数结果差异有统计学意义(P<0.001),经ROC曲线分析RBC-Y、RET-Y和SF在诊断肾性贫血患者铁缺乏时曲线下面积分别为0.811、0.780、0.530,当临界值为151.6时,RBC-Y诊断铁缺乏的灵敏度为81.0%,特异性为75.0%;当临界值为1 580.5时,RET-Y诊断铁缺乏的灵敏度为74.6%,特异性为75.0%;当临界值为96μg/L时,SF诊断铁缺乏的灵敏度为61.9%,特异性为58.3%。结论 RBC-Y和RET-Y可作为CRF引起的肾性贫血患者铁缺乏的诊断指标。

Objective To explore the clinical value of RBC-Y and RET-Y in monitoring the iron deficiency of the patients who suffer with renal anemia .Methods Blood samples were collected from patients with renal anemia of CRF and normal control individuals ,then RBC-Y ,RET-Y ,SF and sTfR were detected respectively and sTfR 〉2 .25 mg/L was regarded as ＂gold standard＂of the iron deficiency ,using ROC curve to analyze RBC-Y ,RET-Y and SF for the diagnosis of the iron deficiency of the patients who suffer with renal anemia was studied .Results There are significant differences in RBC-Y and RET-Y between renal anemia group and control group .The RBC-Y ,RET-Y and SF area under the ROC curve are 0 .811 ,0 .780 ,0 .530 ,the sensitivity of RBC-Y in diagnosing iron deficiency is 81 .0%and specificity is 75 .0% when the critical value is 151 .6 ;sensitivity of RET-Y is 74 .6% and specificity is 75 .0%when the critical value is 1 580 .5;sensitivity of SF is 61 .9% and specificity is 58 .3% when the critical value is 96μg/L .Conclusion RBC-Y and RET-Y could be used as an indicator of iron deficiency in patients with renal anemia of CRF .