黄芩苷对小鼠金黄色葡萄球菌肺炎的保护作用研究

Baicalin alleviates lung injury coused by Staphylococcus aureus pneumonia

目的:研究黄芩苷(Baicalin)对金黄色葡萄球菌肺炎小鼠的保护作用。方法:建立体内金葡菌感染肺炎小鼠模型,检测通过黄芩苷治疗后模型小鼠死亡率、肺湿/干重比例、菌落定植数以及肺泡灌洗液内细胞因子的变化。结果:黄芩苷能够显著降低金葡菌肺炎小鼠的死亡率,小鼠肺脏金葡菌的定植数量及肺脏湿重/干重比;肺泡灌洗液分析试验结果表明,黄芩苷治疗显著减少肺泡灌洗液中主要炎症因子TNF-α、IL-1β和IL-6的含量。结论:黄芩苷可有效治疗小鼠金葡菌肺炎,同时为创新性抗感染药物的研发奠定坚实的基础。

Objective：This study aim to evaluate the effects of baicalin to Staphylococcus aureus（S. aureus） in mice. Methods：The mouse model of S. aurues pneumonia was established to assess the in vivo performance of baicalin, the mortality, lung wet-dry ratio, bacterial count and alteration of cytokine were studied. Results：The results showed that treated mice with baicalin significantly decreased the mortality and the colony forming units （CFUs） in the lung tissues. The lung wet-dry ratio was also reduced, indicating that the pulmonary edema was alleviated. Analysis of bronchoalveolar lavage （BAL）fluid revealed that treated mice with baicalin led to a marked reduction in IL-1β, TNF-α and IL-6 concentrations in BAL fluids. Conclusion：The findings in our study indicated that baicalin protects lung damage from S. aureus, and our study will lay the foundation for development of？innovative？anti-infective drugs.