超声诊断脂肪肝与胰岛素抵抗及代谢综合征的相关性

Association between Insulin Resistance,Metabolic Syndrome and Ultrasound diagnosis of Fatty Liver

目的:探讨超声诊断脂肪肝(NAFLD)与胰岛素抵抗及代谢综合征(MS)的相关性。方法:50例NAFLD患者及56例健康对照者分别进行超声检查,同时测定腰围、血压、空腹血糖、空腹胰岛素、血脂等,计算胰岛素抵抗指数(HOMA-IR),并作相关统计学分析。结果:NAFLD组的MS发病率明显高于对照组(48.0%VS 5.4%,P<0.001),且NAFLD组的HOMA-IR明显高于对照组(2.65±1.35 VS 1.45±1.02,P<0.001)。Logistic回归分析表明年龄,腰围,HOMA-IR为NAFLD的独立危险因素。结论:NAFLD与MS密切相关,胰岛素抵抗是NAFLD的独立危险因素。

Objective To investigate the association between insulin resistance ,metabolic syndrome （MS） and Ultrasound diagnosis of fatty liver. Method Fifty subjects with NAFLD and 56 controls were enrolled for the study. An subjects underwent ultrasound examinations, meanwhile waist circumference, blood pressure, fasting glucose, fasting insulin, serum lipids and homeostasis model assessment of insulin resistance （ HOMA - IR） values as an index used to quantify insulin resistance were measured and analyzed. Logistic regression was analyzed to predict independent risk factors of NAFLD. Results The prevalence of MS in NAFLD group was obviously higher than in controls group （48.0% VS 5.4% ,P 〈0. 001 ） ,and HOMA - IR values in NAFLD group was higher than that of controls group（2. 65 ± 1.35 VS 1.45 ± 1.02,P 〈0. 001 ）. In a logistic regression analysis,age,waist circumference and HOMA -IR were independently associated with the presence of NAFLD. Conclusion NAFLD was closely associated with MS and insulin resistance was a very strong predictor of NAFLD.