陶瓷粉尘对工人呼吸道症状发病影响的Meta分析

Impact of Ceramic Dust Exposure on Prevalence of Workers' Respiratory Symptoms: a Meta Analysis

[目的]探讨陶瓷粉尘对接尘工人呼吸道症状的影响。[方法]分别在维普中文科技期刊数据库、中国知网、万方数字化期刊数据库、PubMed等检索1990至2012年公开发表的关于陶瓷粉尘与工人发生呼吸道症状相关的原始文献,按剔除与纳入标准分类整理后,进行Meta分析,按暴露组与对照组进行分析,计算合并OR值（95%CI）,探讨陶瓷粉尘对工人呼吸道症状影响,并作敏感性分析。[结果]8篇原始文献被纳入作Meta分析,其中6篇英文文献、2篇中文文献,累计对照组812例,暴露组1372例,暴露组发生呼吸道症状的风险是对照组的3.91（95%CI：2.85~4.97）倍。敏感性分析Z=6.73,P〈0.01;Begg检验Z=0.49,P=0.62;Egger检验,t=0.59,P=0.58（95%CI：-1.38~2.26）,即分析结果稳定且不存在明显偏倚。[结论]陶瓷粉尘对接触工人呼吸道症状影响显著。

[ Objective ] To assess the effect of exposure to ceramic dust on the prevalence of workers＇ respiratory symptoms. [ Methods ] Original articles on ceramic dust and the prevalence of respiratory symptoms from 1990 to 2012 were retrieved via the VIP Chinese Science and Technology Periodical Database, the China Knowledge Resource Integrated Database, the Wanfang Med Online, and the PubMed, according to a seff-designed exclusion and inclusion criteria. A meta analysis including a sensitivity analysis were applied to assess the effect by calculating pooled OR （95%C/） for the exposed workers versus the controls. [ Results ] Eight original studies were selected for the meta analysis, including a total of 812 controls and 1 372 cases, among which six were published in English and two in Chinese. The OR of presenting respiratory symptoms was 3.91 （95%CI： 2.85-4.97） in the workers exposed to ceramic dust versus the selected controls. The results of sensitivity analysis showed Z=6.73, P〈0.01; the results of Begg test showed Z=0.49, P=0.62; and the results of Egger test showed t=0.59, P=0.58 （95%CI： -1.38-2.26）, indicating the results were stable and had no significant bias. [ Conclusion ] Workers＇ respiratory symptoms are significantly induced by exposure to ceramic dust at work.