流行性乙型脑炎患者体内干扰素变化的临床意义

Clinical Significance of Interferon Level Change in Patients with Japanese B Encephalitis

目的 :了解流行性乙型脑炎 (乙脑 )患者体内干扰素 (IFN)水平的变化。方法 :采用细胞病变抑制法 (CPE)检测5 1例乙脑患者血清及脑脊液 (CSF)中的IFN水平。结果 :(1)急性期血清及CSF中的IFN水平均显著升高 ,恢复期显著下降 ,但仍明显高于正常对照 ;CSF中的含量高于血液 ,并与病情的严重程度关系密切。 (2 )采用IFN肌肉注射治疗的患者用药后血清中IFN升高 ,但CSF中IFN水平未见升高 ,而且临床主要症状及体征改善与未用IFN组无显著差异。结论 (1)IFN参与了乙型脑炎的发病过程。 (2 )IFN治疗并不能提高疗效 ,临床上不易贸然使用 ,需寻找其它更为有效的抗病毒治疗方法。

Objective To investigate the change of interferon(IFN) level in Japanese B encephalitis patients.Method Cytopathic effect inhibition assay was used to measure IFN level in the serum and cerebrospinal fluid(CSF) of 51 cases of JBE.Results (1)In acute phase,IFN levels increased significantly both in serum and CSF,and decreased significantly in recover phase,but were still higher than those in the healthy control subjects. The levels of IFN in CSF were significantly higher than those in serum,and were highly associated with the severity of the disease.(2)After intramuscalar injected with IFN,the levels of IFN increased significantly in serum,but did not increase in CSF at all.There was no significant improvement of clinical symptoms and signs compared with the group that did not have the administration of IFN.Conclusions (1)IFN plays one of the important roles in Japanese B encephalitis.(2)There are no obvious effects in IFN therapy.So we must search for other antiviral agents.