健康体检者空腹血糖、胰岛素抵抗与血清谷氨酰转肽酶水平的相关性研究

The correlation of fasting blood glucose and insulin resistance with serumγ-GT level in healthy examinees

目的 探讨健康体检者血清谷氨酰转肽酶（γ-GT）与FPG、IR间的关系. 方法 纳入793名健康体检者,根据FPG中位数5.42 mmol/L与胰岛素抵抗指数（HOMA-IR）中位数2.04,分为高FPG（HF）组和正常FPG（NF）组,IR组和IS组,比较各组γ-GT水平. 结果 HF、IR组γ-GT水平均高于NF、IS组（P＜0.01）.Spearman相关分析显示,γ-GT与FPG、FIns及HOMA-IR呈正相关.Logistic回归分析结果显示,FPG（OR=1.615,95％CI：1.208～2.158）、TG（OR=4.104,95％CI：2.650～6.357）、FIns（OR=2.866,95％CI：1.114～7.372）及饮酒情况（OR=3.068,95％CI：1.935～4.864）是γ-GT水平升高的危险因素. 结论 FPG、FIns与血清γ-GT水平相关,γ-GT可能成为T2DM发生风险的预测因素.

Objective To investigate the correlation of serumγ-GT level with blood glucose and insulin resistance in healthy examinees.Methods A total of 793 healthy examinees were enrolled and divided into four groups：high fasting blood glucose （median 5.42 mmol/L,HF） and normal blood glucose （median 5.42 mmol/L,NF）,and insulin resistant group （HOMA-IR median 2.04,IR） and insulin sensitive group （HOMA-IR median 2.04,IS）.The level of γ-GT was compared between groups.Results The levels of γ-GT were significantly higher in HF group than in NF group （P＜0.01）and lower in IR group than in IS group （P＜ 0.01）.Correlation analysis showed that the γ-GT level was positively associated with FPG,FIns and HOMA-IR.Logistic regression analysis indicated that FPG（OR=1.615,95％CI：1.208～2.158）,TG（OR=4.104,95％CI：2.650～6.357）,FIns（OR=2.866,95％CI：1.114～7.372） and drinking status（OR=3.068,95％CI：1.935～4.864） were risk factors for elevated γ-GT level.Conclusion The levels of FPG and insulin resistance are closely related to serum γ-GT level,and γ-GT level might be a predictive factor for T2DM.