期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

microRNA与糖尿病发生发展机制的关系 被引量：2

The relationship of microRNA and diabetes mellitus
原文传递
导出
摘要 microRNA(miRNA)是一类非编码单链小RNA,调控基因转录后的表达。miRNA表达模式具有位相性和时序性。作为一种广泛存在的对基因表达能进行微调的分子,miRNA通过网络调控方式,可从整体上调控生物体的生命活动。近年研究发现,miRNA在糖尿病发生发展中起重要作用。本文就miRNA在胰腺及胰岛素作用靶器官的作用作一综述。 microRNAs （miRNAs） are a short non-coding RNAs that repress target gene expression via post-transcriptional mechanisms.Emerging evidence shows that they have diverse cellular and biological functions and play key roles in several diseases.In this review,we explore the role of miRNAs in the pathology of diabetic mellitus.
作者 张茜 肖新华
机构地区 中国医学科学院北京协和医学院北京协和医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2014年第6期574-576,共3页 Chinese Journal of Diabetes
基金 国家自然科学基金(81170736) 国家自然科学基金青年资助项目(81300649) 国家临床重点专科建设项目
关键词 MICRORNA 糖尿病 基因表达调控 胰腺 胰岛素作用靶组织 microRNA（miRNA） Diabetes mellitus Regulation of gene expression Pancreatic islet Target tissues of insulin action
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献1

二级参考文献26

  • 1American Diabetes Association. Clinical Practice Recommendations 2001. Diabetes Care 2001 24: S1-S133.
  • 2Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R and Hollenbeck A, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006, 355: 763-778.
  • 3Akerblom H. Pathogenesis of Type 1 diabetes: environmental factors. In: Turtle J, Kaneko T and Osato S eds. Diabetes in the New Millennium. Sydney: Endocrinology and Diabetes Research Foundation, University of Sydney, 1999.
  • 4Kahn SE. Clinical review 135: the importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001, 86: 4047-4058.
  • 5Steppan CM, Bailey ST, Bhat S, Brown E J, Banerjee RR, Wright CM and Patel HR, et al. The hormone resistin links obesity to diabetes. Nature 2001, 409: 307-312.
  • 6Portha B. Programmed disorders of B-cell development and fimction as one cause for type 2 diabetes? The GK rat paradigm. Diabetes Metab Res Rev 2005, 21: 495-504.
  • 7Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C and Long J, et al. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rots. J Cell Mol Med 2008; doi:10.1111/ j. 1582-4934.2008.00342.x.
  • 8Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116: 281-297.
  • 9Kato M and Slack FJ. MicmRNAs: small molecules with big roles-C. elegan to human cancer. Biol Cell 2008, 100:71-81.
  • 10Scalbert E and Bril A. Implication of micmRNAs in the cardiovascular system. Curt Opin Pharmacol 2008, 8: 181-188.

共引文献16

同被引文献32

  • 1O" DriseollL. The emerging world of microRNAs [ J ]. Anticancer Res, 2006,26 (6 B) : 4271-4278.
  • 2Lee RC, Feinbaum RL, Arnbros V. The C elegansheteroehronc gene lin-4 eneodes small RNAs with antisense complementarity to lin-14[J]. Cell,1993,75(5) :843-854.
  • 3O Dumortier, E Obberghen. MicroRNAs in pancreas development [J]. Diabetes,Obesity and Metabolism,2012,14(s3) :22-28.
  • 4Esguerra JLS, Mollet IG, Salunkhe VA,et al. Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs [J]. Genes,2014,5(4) : 1018-1031.
  • 5Poy MN,Eliasson L, Krutzfeldt J,et al. A pancreatic islet- specific micro-RNA regulates insulin secretion [J]. Nature, 2004, 432:226-230.
  • 6Baroukh N, Ravier MA, Loder MK, et al. MieroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic β-cell lines [J]. Journal of Biological Chemistry, 2007, 282 (27): 19575-19588.
  • 7Melkman-Zehavi T, Oren R, Kredo-Russo, et al. miRNA control insulin content in pancreatic beta-cells via downregulation of transcriptional repressors [J]. EMBO,2011,30(5) :835-845.
  • 8Yang WY. Prevalence of diabetes among men and women in China[J]. New EngI J Meal,2010:362.
  • 9C Guay, C Jacovett,V Nesca,et al. Emerging roles of non coding RNAs in pancreatic β-cell function and dysfunction [J]. Diabetes,Obesity and Metaboism,2012,(Suppl 3) :12 21.
  • 10Selene L,Ferandez-Valverde,Ryan J,etal. MicroRNAs in β- Cell Biology, Insulin Resistance, Diabetes and Its Complications [J]. Diabetes, 2011,60 : 1825-1831.

引证文献2

二级引证文献5

中国糖尿病杂志
2014年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部