腹腔镜胃穿孔修补术患者围术期血清白介素、应激激素及氧化应激的变化研究

Study on the change of serum interleukin,stress hormones and oxidative stress of patients with laparoscopic repair of gastric perforation during the perioperative period

目的研究及分析腹腔镜胃穿孔修补术患者围术期血清白介素、应激激素及氧化应激的变化状态。方法选取2011年6月-2013年7月于该院进行胃穿孔修补术治疗的60例患者为研究对象,将其根据手术方式分为对照组（开腹手术组）30例和观察组（腹腔镜手术组）30例,然后将两组患者术前和术后不同时间的血清白介素、应激激素及氧化应激检测结果进行比较。结果观察组术后不同时间的血清白介素中的IL-2高于对照组,其他白介素及应激激素均低于对照组,氧化应激指标也均好于对照组,均P〈0.05,差异均有显著性。结论腹腔镜胃穿孔修补术患者围术期血清白介素、应激激素及氧化应激的波动相对较小,说明此类患者的手术性创伤较小且恢复较快。

[Objective] To study and analyze the change state of serum interleukin, stress hormones and oxidative stress of patients with laparoscopic repair of gastric perforation during the perioperative period. [ Methods ] 60 patients with repair of gastric perforation in our hospital from June 2011 to July 2013 were the research object, and 60 cases were divided into control group （open operation group） 30 cases and observation group （laparoseopie operation group） 30 cases according to the operation type, then the serum interleukin, stress hormones and oxidative stress of two groups before the operation and at different time after the operation were compared. [ Results ] The serum IL-2 of intedeukin of observation group at different time after the operation were higher than those of control group, other interleukin and stress hormones were all lower than those of control group, oxidative stress indexes were better than those of control group too, all P 〈0.05, there were all significant differences. [ Conclusions ] The fluctuation of serum interleukin, stress hormones and oxidative stress of patients with laparoscopic repair of gastric perforation during the perioperative period are relatively smaller, and it shows that the operative trauma is smaller and the recovery is faster.