社区获得性肺炎支原体肺炎儿童肝功能分析

Analysis on liver function of children with community- acquired Mycoplasma pneumoniae pneumonia

目的探讨肺炎支原体肺炎（MPP）对儿童肝功能的影响。方法：收集2010年6月-2013年8月在广东医学院附属陈星海医院儿科住院的300例社区获得性MPP儿童为研究对象（MPP组），另选择同期在该院儿保门诊体检的40例健康儿童作为对照组。回顾性分析MPP组患儿的肝功能指标，并与对照组比较，实验数据采用SPSS17．0统计软件处理。结果：MPP组肝功能指标丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）及r-谷氨酰转移酶（GGT）均高于对照组，差异均有统计学意义（P〈0．05）。总胆红素（TBIL）、直接胆红素（DBIL）及间接胆红素（IBIL）两组问比较，差异均无统计学意义（P〉0．05）。肝功能异常10例，发生率为3．33％，多见于婴幼儿。结论：MPP患儿急性期可并发肝功能损害，入院时及治疗期间应注意监测以免加重损害。

Objective To explore the effect of Mycoplasma pneumoniae pneumonia （MPP） on liver function of children. Methods：Three hundred community - acquired MPP children were collected from the hospital from June 2010 to August 2013 as study objects （ MPPgroup） ; 40 healthy children receiving physical examination in the hospital during the same period were selected as control group; liver functionindexes in the two groups were analyzed and compared; the data were analyzed statistically on SPSS17.0 software. Results： The levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST） and γ- glutamyhransferase （GGT） in MPP group were statistically signifi-cantly higher than those in control group （P 〈 0. 05 ） ; there was no statistically significant difference in the levels of total bilirubin, direct bilirubin and indirect bilirubin between the two groups （P 〉 0. 05 ） ; the incidence rate of liver dysfunction was 3.33 % （ 10 patients）, which wascommon in infants. Conclusion： Liver function damage may occur in MPP children during acute period, monitoring should be paid more attention to on admission and during treatment to avoid damage aggravation.