摘要
目的对类过敏反应的症状特点、发生机理、评价方法及存在的问题进行了综述和分析,为类过敏反应的深入研究提供文献依据。方法对近年来有关类过敏反应的国内外文献进行了整理与归纳。结果虽然类过敏反应的症状表现与过敏反应相似,但两者发生机制并不相同,其无需提前致敏、抗体介导,首次接触即可发生,危害严重。目前,类过敏反应的临床前评价方法主要有动物实验和细胞实验,检测指标有组胺、IgE等,其诊断需结合症状特点及生物指标综合判断。结论亟待建立可行的有关类过敏反应的临床前评价方法 。
Objective To provide literature evidences for in-depth study of anaphylactoid reactions through reviewing and analyzing the symptoms, mechanism, evaluation methods and problems. Methods The related references in recent years at home and abroad about anaphylactoid reactions were collected and summarized. Results Although the symptoms are similar with allergic reactions, the mechanism is not same. The anaphylactoid reactions can occur at first contact without prior sensitization and antibody-mediated, the aftermath is serious. Currently, the detecting indicators include histamine, IgE, and so on. The diagnosis requires a overall judgment of characteristic symptoms and biological indicators. Conclusion It＇s urgent to establish viable preclinical evaluation methods about anaphylactoid reactions.
出处
《中国药物警戒》
2014年第6期344-346,共3页
Chinese Journal of Pharmacovigilance
关键词
类过敏反应
机制
评价方法
anaphylactoid reactions
mechanism
evaluation methods
