非清除性异基因外周血干细胞移植后发生重度GVHD2例报告

TWO CASES OF THE SEVER GVHD AFTER NAPBSCT

目的 :提高对非清除性异基因外周血干细胞移植 ( NAPBSCT)及移植后发生重度移植物抗宿主病( GVHD)的认识。方法 :报告该院 2例恶性血液病非清除性异基因外周血干细胞移植后发生重度 GVHD并文献复习。结果 :1例于移植后 6 2天痊愈 ,已健康生存 2 0月 ,另 1例移植后 5 1天死亡。结论 :NAPBSCT为恶性血液病的治疗开辟了新思路。 NAPBCT后可能会发生严重的 GVHD。

Objective:Improve the knowledge of non myeloabalative allogeneic peripheral blood stem cells transplantation(NAPBSCT)and the sever GVHD after NAPBSCT.Methods:Two leukemia cases which suffered from sever GVHD after NAPBSCT were presented and previous reports were reviewed.Results:Ten cases with HLA identical siblings donor were received NAPBSCT.Two of them developed GVHD of degree Ⅲ.One case have cured in 62 day after NMA AUO SCT,Another case died in 51 day after NMA AUO SCT.Conclusion:NAPBSCT make a new road for leukemia.It may have the sever GVHD after NAPBSCT,we should pay attetion.