豆丹醇提物抗疲劳作用的研究

Studies on anti-fatigue effect of alcohol extract of Clanis bilineata Walker

探究豆丹醇提物对小鼠的抗疲劳作用。配制不同浓度的豆丹醇提溶液,将80只小鼠随机分为5组(每组16只,雌雄各半):正常对照组、模型组、西洋参对照组、高浓度豆丹醇提物组、低浓度豆丹醇提物组,建立小鼠衰老模型,分别给予6.25、12.5g/kg豆丹醇提物灌胃,分别观察小鼠负重游泳和爬绳的时间以及其血浆尿素氮、肝糖原、血乳酸含量的变化。结果表明:高浓度豆丹醇提物能显著提高小鼠的运动耐力,延长其游泳(p<0.01)和爬绳的时间(p<0.05),提高小鼠体内肝糖原的储备量(p<0.01),降低运动后乳酸的含量(p<0.01),降低运动后血BUN的增量,加速体内BUN的清除速率(p<0.05);低浓度豆丹醇提物也有显著抗疲劳作用,但效果弱于高浓度。说明豆丹醇提物具有抗疲劳作用。

The role of the Clanis bilineata Walker in the anti-fatigue was studied.80 healthy mice were dividedrandomly into 5 groups（ half male and half female in each group）.Two dose of alcohol extract of C.bilineata Walker（6.25g/kg and 12.5g/kg） ,a blank dose and a dose of Panax quinquefolius was applied to the aging model mice.The swimming and climbing time,the contents of blood urea nitrogen, blood lactic acid and liver glycogen of micewere observed.The results showed that the high dose of alcohol extract of C.bilineata Walker could significantlyprolong the swimming （ p 〈 0.01 ） and climbing time （ p 〈 0.05 ）, improve the moving endurance, decrease thecontents of blood urea nitrogen （ p 〈 0.05） and blood lactic acid （ p 〈 0.01 ） and increase the contents of hepaticglycogen（p 〈0.01 ）after exercise.The low dose of alcohol extract of C.bilineata Walker also had some effect onthose indicators, but was not as significant as the high concentration. C. bilineata Walker. It＇ s concluded thatC.bilineate walker had the function of alleviating physical fatigue.