卵巢肿瘤患者ABO和Rh(D)血型分布情况分析

The association study on blood group types and the incidence of ovarian neoplasm among patients undergone surgery

目的卵巢肿瘤手术患者的ABO和Rh(D)血型构成。方法回顾性分析2002年1月至2013年7月3 134例接受手术治疗的卵巢肿瘤患者(良性344例、恶性2 790例)的ABO和Rh(D)血型构成及良、恶性卵巢肿瘤患者术中输血情况分析。结果良、恶性卵巢肿瘤患者的ABO血型表型构成比的差异有统计学意义(P<0.05),恶性卵巢肿瘤患者O型血的构成比低于良性患者(25.4%vs.31.1%,P<0.05);良恶性卵巢肿瘤Rh(D)血型构成比的差异无统计学意义(P>0.05)。恶性卵巢肿瘤患者术中用血率(67.5%vs.8.1%,P<0.0001)、用血量[8(8,12)U vs.4(2,6)U,P<0.0001]均高于良性肿瘤患者。结论良、恶性卵巢肿瘤的发生与ABO血型可能存在一定的关系,非O型血可能会增加罹患卵巢癌的风险;恶性卵巢肿瘤患者,在手术中接受输血的概率更高,输血量更多。

Objective To explore the underlying correlation between the proportion of blood types and incidence of benign and malignant tumors in patients with ovarian neoplasm undergone surgery. Methods ABO blood group and RhD type of 3 134 patients with ovarian neoplasm （344 benign and 2 790 malignant） who undergone surgery between January 2002 and July 2013 were retrospectively analyzed. The usage of blood components during surgery were also analyzed. Results Patients with benign and malignant ovarian tumors presented wtih different composition of ABO blood group types （P 〈 0.05）, in which less patients with malignant tumors carried O blood group types （25.4% vs. 31.1%, P 〈 0.05）. However, Rh （D） blood group types were not associated with the risk of ovarian cancer （P 〉 0,05）. More patients with malignant tumors had blood component consumption than benign ones （67.5% vs. 8.1%, P 〈 0.0001）, so as the amount of consumption [8（8,12） vs. 4（2,6）, P 〈 0.0001]. Conclusion ABO blood group types might play a role in the development of ovarian tumors and the carriage of non-O blood groups may elevate the risk of ovarian cancer. Patients with malignant tumors tend to receive more blood transfusion during surgery, comparing to patients with benign ones.