壳脂胶囊治疗非酒精性脂肪性肝病临床疗效及疲劳特征观察

Therapeutic Effect of Kezhi Capsule for Nonalcoholic Fatty Liver Diseases and Its Influence on Multidimensional Fatigue Inventory Scores

目的:观察壳脂胶囊治疗非酒精性脂肪性肝病(NAFLD)的临床疗效。方法:将确诊为NAFLD 120例的患者,采用随机数字表法分为2组,治疗组患者口服壳脂胶囊,每次1.25 g,每天3次。对照组口服多烯磷脂酰胆碱胶囊,每次456 mg,每天3次。疗程均为3月。观察治疗前后患者疲劳特征改善情况,检测谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBil)、谷氨酰转肽酶(GGT);血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果:治疗组治疗后ALT、AST、GGT、TC、TG、LDL-C和HDL-C较治疗前改善明显(P<0.01),治疗组ALT、AST、GGT优于对照组(P<0.05,P<0.01)。治疗后治疗组血脂各项指标与对照组比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。2组治疗后,总体疲劳、生理疲劳、精神疲劳、兴趣减少积分都表现为降低的趋势(P<0.01),治疗组与对照组各项疲劳特征积分比较,差异均有非常显著性意义(P<0.01)。结论:壳脂胶囊能有效改善NAFLD患者的肝功能,有效降低血脂,并能明显改善患者的疲劳特征。

Objective： To observe the therapeutic effect of Kezhi capsule for nonalcoholic fatty liver disease（NAFLD）. Methods= One hundred and twenty patients with NAFLD were randomized into two groups. The patients in the treatment group were treated with Kezhi capsule, 1.25 g each time and three times per day. The control group were treated with polyene phosphatidyL choline capsules, 456mg each time and three times per day. The treatment lasted 3 months. Before and after treatment, we observed the serum levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, total bilirubin （TBil）, gamma-glutarmyl transpeptidase （GGT）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, and low density lipoprotein cholesterol （LDL-C） as well as the scores of Multidimensional Fatigue Inventory（MFI-20）. Results： Indexes of ALT, AST, GGT, TC, TG, LDL-C, and HDL-C in the treatment group were significantly improved after treatment（P〈 0.01 compared with those before treatment）, and the improvement was superior to that in the control group（P〈0.05, P〈0.01）. The scores of all MFI-20 dimensions of total fatigue, physiological fatigue, mental fatigue, and reduced motivation in both groups were decreased after treatment（P 〈 0.01 compared with those before treatment）, and the difference between the two groups was significant（P〈 0.01） after treatment. Conclusion： Kezhi capsule is effective on significantly ameliorating liver function, blood lipids and Multidimensional Fatigue Inventory scores for NAFLD patients.