摘要
流感病毒RNA聚合酶是由PB2,PB1,PA三个亚基组成的蛋白质复合物,分别由流感基因片段1,2,3编码。在流感病毒基因组RNA复制,病毒mRNA转录以及维持病毒生命周期中发挥着重要作用。近年来随着对其深入研究,为抗流感病毒药物的研制奠定了基础。本文主要介绍了RNA聚合酶各个亚基的结构、功能,亚基间相互作用以及RNA酶抑制剂的研究进展。
Influenza virus RNA polymerase is composed of three viral proteins: PB2, PB1 and PA. They were coded by the influenza gene fragments 1, 2 and 3, respectively. The RNA polymerase plays an important role in the RNA replication of influenza virus, the viral mRNA transcription and the maintenance of the virus life cycle. Recently, many studies of influenza virus RNA polymerase have laid the foundation for the development of anti-in- fluenza virus drugs. In this paper, we introduced the research progress of the structure and function of each subunit of RNA polymerase, and the interactions between subunits and inhibitors against influenza RNA polymerase.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2014年第12期1390-1397,共8页
Chinese Journal of New Drugs
基金
863计划重大项目(2012AA02A401)
国家"重大新药创制"科技重大专项(2013ZX10004003)
关键词
流感病毒
RNA聚合酶
亚基结构与功能
聚合酶抑制剂
influenza virus
RNA polymerase
structure and function of subunits
RNA polymerase inhibitor