结肠定位给药系统的体内外评价方法

Evaluation methods of colon specific drug delivery system in vitro and in vivo

本文介绍近年来口服结肠定位给药系统的评价方法。查阅了国内外相关文献资料,对结肠定位的体内外评价方法进行总结和归纳。随着新机制和新辅料的不断出现,其评价方法缺乏统一的标准,所得数据也存在一定的缺陷。研究新的完善的评价方法是相关工作者人员以后努力的方向,有必要多种方法联合应用研究体内外的释药行为。完善的评价方法是结肠定位给药系统释药机制和体内相互作用的可靠依据。

In this paper, we introduced evaluation methods of colon specific drug delivery system for oral administration in recent years. By reviewing the relevant literature, we summarized the evaluation methods of colon specific drug delivery system. The new mechanism and new materials continue to emerge, but the lack of uniform standards and the data is a defection of these evaluation methods. Comprehensive application of evaluation methods is a direction. It is necessary to combine several methods to research the release behavior in vitro and in vivo. The release mechanism and interaction in vivo of colon specific drug delivery system should be studied based on perfect evaluation methods.