MECT合并小剂量阿立哌唑治疗精神分裂症120例对照研究

Control study of MECT combined with small-dose aripiprazole in treatment of 120 cases with schizophrenia

目的:探讨无抽搐电休克(MECT)技术合用阿立哌唑与单用阿立哌唑治疗精神分裂症的疗效差异。方法:按患者入院先后顺序随机分为三组:A组(MECT治疗组)患者40例,麻醉剂丙泊酚,MECT治疗结束后给予患者阿立哌唑继续治疗;B组(阿立哌唑治疗组)患者40例;C组(MECT治疗+小剂量阿立哌唑治疗组)患者40例。三组患者分别用MECT治疗9次。患者分别于治疗前和治疗后的1、2、3、5及7周评定阴性与阳性症状量表(PANSS)与副反应量表(TESS)。结果:同时合用小剂量阿立哌唑组患者PANSS评分下降最明显。结论:MECT联合阿立哌唑治疗精神分裂症患者起效快,疗效好,不良反应少。

Objective：To compare the difference of clinical efficacy of modified electronic conclusive therapy（MECT）com-bined with aripiprazoleand single aripiprazolein treatment of schizophrenia. Methods：The patients with schizophrenia were randomly divided into 3 groups according to the order of entering into the hospital and each group had 40 cases：group A（MECT group）,group B（aripiprazole group）and group C（MECT combined with small-dose aripiprazolegroup）. In eachgroup,MECT was conductedfor nine times. All groups were assessed withpositive and negative syndrome scale（PANSS）and treatment emergent syndrome scale（TESS） before and 1,2,3,5 and 7 weeks after the treatment. Results：The decrease of the PANSS score in group Cwas more obvious than those in other groups. Conclusions：MECT combined with small-dose aripiprazole is an ideal therapy for the patients with schizophreni-a with more rapid and good effectsand less side reactions.